{"id":19664,"date":"2018-03-09T09:08:43","date_gmt":"2018-03-09T09:08:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-expresion-vascular-del-vegf-y-del-vegfr-2-en-la-hipercolesterolemia-experimental-y-su-modulacion-por-las-vitaminas-c-y-e\/"},"modified":"2018-03-09T09:08:43","modified_gmt":"2018-03-09T09:08:43","slug":"analisis-de-la-expresion-vascular-del-vegf-y-del-vegfr-2-en-la-hipercolesterolemia-experimental-y-su-modulacion-por-las-vitaminas-c-y-e","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/analisis-de-la-expresion-vascular-del-vegf-y-del-vegfr-2-en-la-hipercolesterolemia-experimental-y-su-modulacion-por-las-vitaminas-c-y-e\/","title":{"rendered":"An\u00e1lisis de la expresi\u00f3n vascular del vegf y del vegfr-2 en la hipercolesterolemia experimental y su modulaci\u00f3n por las vitaminas c y e"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Nespereira Rodr\u00edguez <\/strong><\/h2>\n<p>El factor de crecimiento del endotelio vascular (vegf) presenta un doble papel en la homeostasis vascular, puesto que es el responsable del mantenimiento de la integridad endotelial, pero tambi\u00e9n podr\u00eda favorecer el desarrollo de la placa ateroscler\u00f3tica al promover la angiog\u00e9nesis a trav\u00e9s de su receptor vegfr-2. El objetivo de este estudio fue determinar si la expresi\u00f3n de este factor de crecimiento y su receptor estaba aumentada en la hipercolesterolemia debido al incremento del estr\u00e9s oxidativo, y si la administraci\u00f3n de vitaminas c y e podr\u00eda reducir esta sobreexpresi\u00f3n. Para ello utilizamos, in vivo, ratones apoe deficientes de 2 meses, sin aterosclerosis establecida, y de 5 meses, que ya presentaban lesiones ateroscler\u00f3ticas macrosc\u00f3picamente visibles, a los que les administramos \u00e1cido asc\u00f3rbico y alfa o beta-tocoferol e, in vitro, cultivos de c\u00e9lulas endoteliales de coronaria porcina estimulados con ldl procedentes de cerdos hipercolesterol\u00e9micos (ldl-hc).  los ratones apoe deficientes preateroscler\u00f3ticos mostraron un elevado estr\u00e9s oxidativo y mayor expresi\u00f3n vascular de vegf y vegfr-2 que los ratones normales. El tratamiento con vitaminas redujo la expresi\u00f3n del vegf en parte a trav\u00e9s de la actividad antioxidante de las vitaminas y en parte por las propiedades no antioxidantes. Las vitaminas tambi\u00e9n disminuyeron la expresi\u00f3n del vegfr-2 mediante sus propiedades antioxidantes. En los ratones apoe deficientes ateroscler\u00f3ticos se observ\u00f3 que el tratamiento con vitaminas c y e provoc\u00f3 una tendencia a la reducci\u00f3n de la extensi\u00f3n de las lesiones y de la neovascularizaci\u00f3n de las mismas.  la estimulaci\u00f3n de cultivos de c\u00e9lulas endoteliales con ldl-hc provoc\u00f3 un incremento de la expresi\u00f3n del vegf y su receptor vegfr-2, efecto que no caus\u00f3 el tratamiento con ldl procedentes de cerdos control ni con ldl de cerdos que siguieron dieta hipercolesterol\u00e9mica suplementada con vitaminas c y e. Las vitaminas c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la expresi\u00f3n vascular del vegf y del vegfr-2 en la hipercolesterolemia experimental y su modulaci\u00f3n por las vitaminas c y e<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la expresi\u00f3n vascular del vegf y del vegfr-2 en la hipercolesterolemia experimental y su modulaci\u00f3n por las vitaminas c y e <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Nespereira Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodr\u00edguez Garc\u00eda Jos\u00e9 Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Jes\u00fas Lopez zabalza <\/li>\n<li>Antonio L\u00f3pez farr\u00e9 (vocal)<\/li>\n<li>Jes\u00fas Herrero gonz\u00e1lez (vocal)<\/li>\n<li>Jos\u00e9 Martinez gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Nespereira Rodr\u00edguez El factor de crecimiento del endotelio vascular (vegf) presenta un doble papel en la 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