{"id":19686,"date":"2018-03-09T09:08:45","date_gmt":"2018-03-09T09:08:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/adhesion-celular-al-dominio-de-union-a-heparina-iii-de-fibronectina-implicacion-en-reorganizacion-del-citoesqueleto-y-migracion-celular\/"},"modified":"2018-03-09T09:08:45","modified_gmt":"2018-03-09T09:08:45","slug":"adhesion-celular-al-dominio-de-union-a-heparina-iii-de-fibronectina-implicacion-en-reorganizacion-del-citoesqueleto-y-migracion-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/adhesion-celular-al-dominio-de-union-a-heparina-iii-de-fibronectina-implicacion-en-reorganizacion-del-citoesqueleto-y-migracion-celular\/","title":{"rendered":"Adhesi\u00f3n celular al dominio de uni\u00f3n a heparina iii de fibronectina. implicaci\u00f3n en reorganizaci\u00f3n del citoesqueleto y migraci\u00f3n celular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Vicente Moyano  Idoeta <\/strong><\/h2>\n<p>La fibronectina (fn) es una glicoprote\u00edna de la matriz extracelular (mec) capaz de mediar adhesi\u00f3n celular, destacando el dominio central de uni\u00f3n a c\u00e9lulas con la secuencia rgd, ligando de las integrinas alfa5beta1 y alfavbeta3. La fn contiene adem\u00e1s tres dominios de uni\u00f3n a heparina denominados i, ii y iii. En esta tesis doctoral se han estudiado con detalle las propiedades bioqu\u00edmicas y biol\u00f3gicas del dominio de uni\u00f3n a heparina iii (hep iii) de la fn. Se han identificado dos nuevas secuencias mediadoras de adhesi\u00f3n dentro de este dominio (concretamente en la repetici\u00f3n iii5 de la fn), denominadas h2 y hbp\/iii5. El sitio h2 es capaz de mediar adhesi\u00f3n de diferentes c\u00e9lulas linfoides b y t, as\u00ed como de melanoma, a trav\u00e9s de las integrinas alfa4beta1 y alfa4beta7 en estado activado (con mn2+ o con el anticuerpo monoclonal anti-beta1 ts2\/16), pero no en el basal. El sitio hbp\/iii5 media tambi\u00e9n adhesi\u00f3n celular, pero a trav\u00e9s de proteoglicanos de tipo condroit\u00edn-sulfato (pgs). Ambos sitios son activos en el contexto del fragmento recombinante fn-iii4-5, correspondiente al dominio hep iii de la fn. La adhesi\u00f3n al framgento fn-iii4-5 implica la cooperaci\u00f3n de ambos receptores (integrina alfa4 y pgcs) aunque la contribuci\u00f3n de cada uno de ellos depende del m\u00e9todo de activaci\u00f3n de la integrina alfa4 empleado (mn2+, o ts2\/19). Adem\u00e1s, este fragmento une heparina con alta avidez, equiparable a la del dominio de alta afinidad hep ii.  tambi\u00e9n se ha estudiado la posible implicaci\u00f3n del dominio hep iii de la fn en la reorganizaci\u00f3n de citoesqueleto y regulaci\u00f3n de adhesiones focales inducidas por adhesi\u00f3n a trav\u00e9s de alfa5beta1, ya que podr\u00eda jugar un papel similar al descrito para el dominio hep ii. Para ello, se utilizaron c\u00e9lulas de melanoma skmel-178 que expresan las integrinas alfa4beta1, alfa5beta1, as\u00ed como pgcs, y porque los linfocitos no son capaces de reorganizar el citoesqueleto. La presencia del fragmen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Adhesi\u00f3n celular al dominio de uni\u00f3n a heparina iii de fibronectina. implicaci\u00f3n en reorganizaci\u00f3n del citoesqueleto y migraci\u00f3n celular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Adhesi\u00f3n celular al dominio de uni\u00f3n a heparina iii de fibronectina. implicaci\u00f3n en reorganizaci\u00f3n del citoesqueleto y migraci\u00f3n celular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Vicente Moyano  Idoeta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Pardo M. \u00e1ngeles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>senen Vilar\u00f3 coma (vocal)<\/li>\n<li>joaqu\u00edn Teixid\u00f3 calvo (vocal)<\/li>\n<li>alicia Garc\u00eda arroyo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Vicente Moyano Idoeta La fibronectina (fn) es una glicoprote\u00edna de la matriz extracelular (mec) capaz de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[29780,14425,60331,24376,60330,12984],"class_list":["post-19686","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-alicia-garcia-arroyo","tag-francisco-sanchez-madrid","tag-garcia-pardo-m-angeles","tag-joaquin-teixido-calvo","tag-jose-vicente-moyano-idoeta","tag-senen-vilaro-coma"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19686"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19686\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}