{"id":19739,"date":"2018-03-09T09:08:49","date_gmt":"2018-03-09T09:08:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inhibicion-de-la-apoptosis-y-acumulo-de-alteraciones-geneticas-en-la-progresion-metastasica-del-cancer-de-mama-variabilidad-genetica-y-seleccion-poblacional\/"},"modified":"2018-03-09T09:08:49","modified_gmt":"2018-03-09T09:08:49","slug":"inhibicion-de-la-apoptosis-y-acumulo-de-alteraciones-geneticas-en-la-progresion-metastasica-del-cancer-de-mama-variabilidad-genetica-y-seleccion-poblacional","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inhibicion-de-la-apoptosis-y-acumulo-de-alteraciones-geneticas-en-la-progresion-metastasica-del-cancer-de-mama-variabilidad-genetica-y-seleccion-poblacional\/","title":{"rendered":"Inhibici\u00f3n de la apoptosis y ac\u00famulo de alteraciones gen\u00e9ticas en la progresi\u00f3n metast\u00e1sica del c\u00e1ncer de mama: variabilidad gen\u00e9tica y selecci\u00f3n poblacional"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Olga M\u00e9ndez Fern\u00e1ndez <\/strong><\/h2>\n<p>En un grupo de tumores de mama se decici\u00f3 estudiar si la p\u00e9rdida de funci\u00f3n de la prote\u00edna bax pod\u00eda ser debida a la existencia de mutaciones frameshift. los resultados obtenidos sugieren que en c\u00e1ncer de mama, las mutaciones del gen bax no ser\u00edan cr\u00edticas para la carcinog\u00e9nesis y el proceso de progresi\u00f3n tumoral. Este tipo de mutaciones s\u00f3lo se han detectado en tumores con inestabilidad de microsat\u00e9lites, por lo tanto decidimos estudiar cual era la incidencia de este tipo de alteraci\u00f3n en nuestro grupo de tumores, encontrando que un 11,6% era inestables.  la inestabilidad detectada qued\u00f3 delimitada a las secuencias que afectaban a dinucle\u00f3tidos, no se encontr\u00f3 ninguna alteraci\u00f3n en las secuencias de mononucle\u00f3tidos analizadas. Se encontr\u00f3 una asociaci\u00f3n estad\u00edsticamente significativa entre la existencia de inestabilidad de microsat\u00e9lites y la p\u00e9rdida de apoptosis observada en los tumores. La mayor supervivencia celular  resultado de la p\u00e9rdida de apoptosis podr\u00eda favorecer la existencia de este tipo de alteraci\u00f3n en los tumores.  para corroborar si la p\u00e9rdida de apoptosis se pod\u00eda asociar a la existencia de inestabilidad de forma gen\u00e9rica en los tumores de mama, se decidi\u00f3 estudiar si la sobreexpresi\u00f3n de las prote\u00ednas antiapopt\u00f3ticas bcl-2 y bcl-xl era capaz de inducir un ac\u00famulo de alteraciones gen\u00e9ricas, y el efecto que las mismas pod\u00edan tener sobre el proceso de progresi\u00f3n tumoral.  al analizar el da\u00f1o gen\u00f3mico en las l\u00edneas transfectadas con respecto a la l\u00ednea parental, los transfectantes con genes antiapot\u00f3ticos ten\u00edan un gdf mayor que los transfectantes en el gen control por lo tanto, la inhibici\u00f3n de la apoptosis era capaz de inducir un aumento en el n\u00famero de alteraciones gen\u00e9ticas detectables por ap-pcr, contribuyendo as\u00ed a la inestabilidad gen\u00e9tica que caracteriza a las c\u00e9lulas tumorales. El an\u00e1lisis filogen\u00e9tico de las l\u00edneas transfectadas, con respecto a la l\u00ednea parent<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inhibici\u00f3n de la apoptosis y ac\u00famulo de alteraciones gen\u00e9ticas en la progresi\u00f3n metast\u00e1sica del c\u00e1ncer de mama: variabilidad gen\u00e9tica y selecci\u00f3n poblacional<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inhibici\u00f3n de la apoptosis y ac\u00famulo de alteraciones gen\u00e9ticas en la progresi\u00f3n metast\u00e1sica del c\u00e1ncer de mama: variabilidad gen\u00e9tica y selecci\u00f3n poblacional <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Olga M\u00e9ndez Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/10\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00c1\u00a0ngels Sierra Jim\u00e9nez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: isidre Ferrer <\/li>\n<li>daniel Grinberg vaisman (vocal)<\/li>\n<li>ram\u00f3n Mangues bafalluy (vocal)<\/li>\n<li>Miguel angel Peinado morales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Olga M\u00e9ndez Fern\u00e1ndez En un grupo de tumores de mama se decici\u00f3 estudiar si la p\u00e9rdida de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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