{"id":19772,"date":"2002-05-11T00:00:00","date_gmt":"2002-05-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-caracterizacion-farmacotecnica-y-farmacologica-de-nuevas-formulaciones-parenterales-de-anfotericina-b\/"},"modified":"2002-05-11T00:00:00","modified_gmt":"2002-05-11T00:00:00","slug":"desarrollo-y-caracterizacion-farmacotecnica-y-farmacologica-de-nuevas-formulaciones-parenterales-de-anfotericina-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-caracterizacion-farmacotecnica-y-farmacologica-de-nuevas-formulaciones-parenterales-de-anfotericina-b\/","title":{"rendered":"Desarrollo y caracterizaci\u00f3n farmacot\u00e9cnica y farmacol\u00f3gica de nuevas formulaciones parenterales de anfotericina b"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Brime Beteta <\/strong><\/h2>\n<p>El objetivo principal de esta tesis doctoral ha sido el desarrollo farmacot\u00e9cnico y farmacol\u00f3gico de nuevas formulaciones parenterales de anfotericina b en forma de microemulsiones destinadas al tratamiento de micosis sist\u00e9micas asociadas a estados de inmunodepresi\u00f3n, que mejoren desde los puntos de vista toxicol\u00f3gico, farmacocin\u00e9tico y de eficacia a las formulaciones de anfotericina b ya comercializadas. Para ello se dise\u00f1aron diversas formulaciones del f\u00e1rmaco en microemulsiones parenterales, se realiz\u00f3 la comparaci\u00f3n de distinas t\u00e9cnicas de emulsificaci\u00f3n y de distintos tensioactivos.  se caracterizaron las microemulsiones por pcs, y se realizaron estudios de viscosidad. Tambi\u00e9n se evalu\u00f3 el contenido en principio activo de las microemulsiones y se evalu\u00f3 su estabilidad. Se realizaron estudios farmacocin\u00e9ticos en animales de experimentaci\u00f3n (conejos), usando diferentes dosis y mdos de administraci\u00f3n de estas nuevas formulaciones de anfotericina b para determinar la cin\u00e9tica de distribuci\u00f3n y eliminaci\u00f3n del f\u00e1rmaco en comparaci\u00f3n con la formulaci\u00f3n comercial fungizona(r). Se realiz\u00f3 un primer ensayo de las formulaciones tras la administraci\u00f3n de una dosis de 1mg\/kg en bolus i.V., Con el fin de realizar un estudio comparativo del comportamiento farmacocin\u00e9tico de las distintas formulaciones. Se realiz\u00f3 un segundo estudio mediante la administraci\u00f3n de diferentes dosis de una de las microemulsiones administradas por v\u00eda i.V., En bolus, con el fin de comprobar la posible farmacocin\u00e9tica dosis dependiente. Por \u00faltimo se realiz\u00f3 un estudio comparativo de una de las microemulsiones y la formulaci\u00f3n comercial (fungizona (r) ), tras se administradas por perfusi\u00f3n i.V., En una dosis de 1 mg\/kg durante 4 d\u00edas en conejos con el fin de realizar un estudio comparativo de ambas formulaciones seg\u00fan se emplean a nivel hospitalario para el tratamiento de micosis sist\u00e9micas. El uso de la anfotericina b por v\u00eda paren<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y caracterizaci\u00f3n farmacot\u00e9cnica y farmacol\u00f3gica de nuevas formulaciones parenterales de anfotericina b<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y caracterizaci\u00f3n farmacot\u00e9cnica y farmacol\u00f3gica de nuevas formulaciones parenterales de anfotericina b <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Brime Beteta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Paloma Frutos Cabanillas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li>Jos\u00e9 Martinez lanao (vocal)<\/li>\n<li>p. Bettini ruggero (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Alonso fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Brime Beteta El objetivo principal de esta tesis doctoral ha sido el desarrollo farmacot\u00e9cnico y farmacol\u00f3gico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[60525,5847,9410,52382,60526,6924],"class_list":["post-19772","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-begona-brime-beteta","tag-jose-luis-lastres-garcia","tag-jose-Martinez-lanao","tag-maria-jose-alonso-fernandez","tag-p-bettini-ruggero","tag-paloma-frutos-cabanillas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19772"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19772\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}