{"id":19776,"date":"2002-05-11T00:00:00","date_gmt":"2002-05-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-del-papel-pronostico-de-la-deteccion-inmunohistoqua%c2%admica-de-las-micrometastasis-ganglionares-ocultas-en-pacientes-con-carcinoma-colorrectal-en-estado-t3n0m0\/"},"modified":"2002-05-11T00:00:00","modified_gmt":"2002-05-11T00:00:00","slug":"valoracion-del-papel-pronostico-de-la-deteccion-inmunohistoqua%c2%admica-de-las-micrometastasis-ganglionares-ocultas-en-pacientes-con-carcinoma-colorrectal-en-estado-t3n0m0","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/valoracion-del-papel-pronostico-de-la-deteccion-inmunohistoqua%c2%admica-de-las-micrometastasis-ganglionares-ocultas-en-pacientes-con-carcinoma-colorrectal-en-estado-t3n0m0\/","title":{"rendered":"Valoraci\u00f3n del papel pron\u00f3stico de la detecci\u00f3n inmunohistoqu\u00edmica de las micromet\u00e1stasis ganglionares ocultas en pacientes con carcinoma colorrectal en estado t3n0m0"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda Saenz Jos\u00e9 Angel <\/strong><\/h2>\n<p>Hip\u00f3tesis  los pacientes con c\u00e1ncer colorrectal (ccr) t3n0m0 en los que se detecten microinvasi\u00f3n ganglionar con anticuerpos anti-citoqueratinas tienen una evaluaci\u00f3n cl\u00ednica peor.  objetivos  determinar el papel pron\u00f3stico de las micromet\u00e1stasis ganglionares ocultas en pacientes con ccr estadio t3n0m0, detectadas con anticuerpos anti-citoqueratinas. determinar la validez diagn\u00f3stica de la tinci\u00f3n.  material y m\u00e9todo  estudio retrospectivo de casos incidentes con diagn\u00f3stico de ccr estad\u00edo t3n0m0; operados en hospital cl\u00ednico de Madrid entre 1988 y 1996. Muestra ganglionar. Seguimiento cl\u00ednico hasta la actualidad.  t\u00e9cnicas inmunohistoqu\u00edmica: anticuerpos monoclonales frente queratina ae1-ae3.  estudio epidemiol\u00f3gico: descripci\u00f3n estad\u00edstica. An\u00e1lisis de la supervivencia. an\u00e1lisis univariante. An\u00e1lisis multivariante. Validez de la prueba.  resultados  resultados inmunohistoqu\u00edmicos: se observ\u00f3 micromet\u00e1stasis en 26 pacientes.  resultados cl\u00ednicos: proporci\u00f3n h:m fue 1,8:1. Edad media: 62,5 a\u00f1os. No recidiva: 79%. Supervivencia global: 81%. El porcentaje de progresi\u00f3n y muerte por sexo no alcanz\u00f3 la significaci\u00f3n estad\u00edstica. La progresi\u00f3n seg\u00fan la edad fue menor entre 45 y 72 a\u00f1os (estad\u00edsticamente significativos). no hubo diferencias de progresi\u00f3n seg\u00fan la localizaci\u00f3n del tumor, el tipo de cirug\u00eda, o el ant\u00edgeno carcinoembrionario prequ\u00edrurgico. La progresi\u00f3n tumoral en funci\u00f3n del tratamiento adyuvante fue mayor en los enfermos que no recibieron tratamiento alguno (estad\u00edsticamente significativo). no hubo diferencias en progresi\u00f3n seg\u00fan el n\u00fameo de ganglios estudiados, o el n\u00famero de ganglios con micromet\u00e1stasis. An\u00e1lisis multivariable fueron estad\u00edsticamente significativos: edad y tratamiento adyuvante. Validez de la prueba: sensibilidad: 27,3%; especificidad: 75,9%; vpp:23,1%; vpn:79,8%, rpp: 1,13; rpn: 0,96; exactitud: 65,71%.  conclusion  no recomendamos realizar t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoraci\u00f3n del papel pron\u00f3stico de la detecci\u00f3n inmunohistoqu\u00edmica de las micromet\u00e1stasis ganglionares ocultas en pacientes con carcinoma colorrectal en estado t3n0m0<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoraci\u00f3n del papel pron\u00f3stico de la detecci\u00f3n inmunohistoqu\u00edmica de las micromet\u00e1stasis ganglionares ocultas en pacientes con carcinoma colorrectal en estado t3n0m0 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda Saenz Jos\u00e9 Angel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Diaz Rubio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jes\u00fas Cruz hern\u00e1ndez <\/li>\n<li>alfredo Carrato menna (vocal)<\/li>\n<li>Luis felix Valero Juan (vocal)<\/li>\n<li>enrique Aranda aguilar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda Saenz Jos\u00e9 Angel Hip\u00f3tesis los pacientes con c\u00e1ncer colorrectal (ccr) t3n0m0 en los que se detecten [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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