{"id":19822,"date":"2002-08-11T00:00:00","date_gmt":"2002-08-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-al-estudio-farmacognostico-de-las-algas-pardas-bifurcaria-bifurcata-r-ross-y-sargassum-muticum-yendo-fensholt\/"},"modified":"2002-08-11T00:00:00","modified_gmt":"2002-08-11T00:00:00","slug":"contribucion-al-estudio-farmacognostico-de-las-algas-pardas-bifurcaria-bifurcata-r-ross-y-sargassum-muticum-yendo-fensholt","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribucion-al-estudio-farmacognostico-de-las-algas-pardas-bifurcaria-bifurcata-r-ross-y-sargassum-muticum-yendo-fensholt\/","title":{"rendered":"Contribuci\u00f3n al estudio farmacogn\u00f3stico de las algas pardas bifurcaria bifurcata r. ross y sargassum muticum (yendo) fensholt"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  M\u00e9ndez De Ara\u00fajo Susana <\/strong><\/h2>\n<p>En el desarrollo de esta tesis doctoral se ha pretendido ampliar los conocimientos farmacol\u00f3gicos existentes, hasta el momento, acerca de los fucanos (polisac\u00e1ridos sulfatados) de dos especies de algas pardas, cuya presencia es habitual en el litoral de la costa gallega: bifurcaria bifurcata y sargassum muticum. Para ello, se procedi\u00f3 a la extracci\u00f3n de los polisac\u00e1ridos a partir de los extractos secos correspondientes, mediante la aplicaci\u00f3n del m\u00e9todo de mian y percival (1973), y a su posterior fraccionamiento a trav\u00e9s de sucesivas cromatograf\u00edas de intercambio i\u00f3nico. Una vez obtenidas las distintas fracciones de fucanos, se llevaron a cabo toda una serie de estudios encaminados a determinar tanto su estructura qu\u00edmica (grado de sulfataci\u00f3n; contenido en az\u00facares reductores, ac\u00eddos ur\u00f3nicos y fucosa; peso molecular; determinaci\u00f3n de sus espectros de infrarrojos y de sus cromatogramas de hplc) como su actividad farmacol\u00f3gica (efecto sobre los par\u00e1metros lip\u00eddicos en distintos modelos de animales normolip\u00e9micos e hiperlip\u00e9micos; efecto sobre la actividad de la enzima lipoprotein lipasa; efecto sobre la agregaci\u00f3n plaquetaria; y, efecto sobre el proceso de la coagulaci\u00f3n sangu\u00ednea).  con ello, se ha podido constatar que, a determinadas concentraciones (2.5,5 y 10 mg de fucano por kg de peso ) son capaces de modificar positivamente los niveles de colesterol total, triglic\u00e9ridos, colesterol ligado a las hdl y colesterol ligado a las ldl en el plasma de ratas, as\u00ed como estimular la actividad de la lpl, que es la principal eznima implicada en el metabolismo de las lipoprote\u00ednas plasm\u00e1ticas, de una manera similar a como lo hace la heparina, que es su activador ex\u00f3geno m\u00e1s importante. Corroborando los resultados de otros estudios, los fucanos se mostraron como potentes anticoagulantes, siendo capaces de incrementar los tiempos de trombina, protrombina y de parcial de tromboplastina activada de manera proporcional a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribuci\u00f3n al estudio farmacogn\u00f3stico de las algas pardas bifurcaria bifurcata r. ross y sargassum muticum (yendo) fensholt<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribuci\u00f3n al estudio farmacogn\u00f3stico de las algas pardas bifurcaria bifurcata r. ross y sargassum muticum (yendo) fensholt <\/li>\n<li><strong>Autor:<\/strong>\u00a0  M\u00e9ndez De Ara\u00fajo Susana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Lamela Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Calleja suarez <\/li>\n<li>Jos\u00e9 Jim\u00e9nez mart\u00edn (vocal)<\/li>\n<li>lu\u00eds Bravo d\u00edaz (vocal)<\/li>\n<li>diego m. Cortes mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00e9ndez De Ara\u00fajo Susana En el desarrollo de esta tesis doctoral se ha pretendido ampliar los conocimientos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,489,957,6530,977],"tags":[2514,21763,2448,22802,53143,60646],"class_list":["post-19822","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacognosia","category-farmacologia","category-farmacologia-experimental","category-santiago-de-compostela","tag-diego-m-cortes-Martinez","tag-jose-jimenez-martin","tag-jose-maria-calleja-suarez","tag-luis-bravo-diaz","tag-manuel-lamela-gonzalez","tag-mendez-de-araujo-susana"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19822"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19822\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}