{"id":19825,"date":"2002-08-11T00:00:00","date_gmt":"2002-08-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-prolactina-sobre-la-diferenciacion-intrata%c2%admica-de-rata\/"},"modified":"2002-08-11T00:00:00","modified_gmt":"2002-08-11T00:00:00","slug":"efecto-de-la-prolactina-sobre-la-diferenciacion-intrata%c2%admica-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-prolactina-sobre-la-diferenciacion-intrata%c2%admica-de-rata\/","title":{"rendered":"Efecto de la prolactina sobre la diferenciaci\u00f3n intrat\u00edmica de rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paz Carolina Carre\u00f1o Palacios <\/strong><\/h2>\n<p>La diferenciaci\u00f3n de los timocitos se inicia en la vida fetal y es un proceso din\u00e1mico altamente regulado por una compleja red neuroendocrina. analizamos la expresi\u00f3n del prlr como una primera aproximaci\u00f3n al estudio de los posibles efectos de la prl sobre la maduraci\u00f3n de los timocitos.  se detectaron la isoforma corta y la larga del prlr a partir del d\u00eda 15 de gestaci\u00f3n y, adem\u00e1s, el 50% de las c\u00e9lulas precursoras t\u00edmicas (cd45+) expresaron el prlr.  para el estudio del papel de prl en la maduraci\u00f3n de los timocitos utilizamos ftocs de 15 y 16 d\u00edas de gestaci\u00f3n mantenidos en presencia o ausencia de prl, de anticuerpos anti-prl \u00f3 anti-prlr, anti-prlr, anti-il2r e il2 en distintas combinaciones.  los datos obtenidos demuestran que la presencia de prl en los ftocs incrementa significativamente la celularidad y el grado de diferenciaci\u00f3n de los timocitos, principalmente cuanto los ftocs son establecidos a partir de l\u00f3bulos t\u00edmicos fetales de 15 d\u00edas. Estos efectos de prl estar\u00edan mediados por il2.  la prl tambi\u00e9n incrementa la capacidad proliferativa y la viabilidad de las c\u00e9lulas cd45+, sin embargo, la capacidad de las c\u00e9lulas cd45+ de colonizar los l\u00f3bulos t\u00edmicos no parece ser afectada. Finalmente, se detecto que cerca del 90% de las c\u00e9lulas dendr\u00edticas t\u00edmicas expresan el prlr y que su grado de madurez se incrementa con prl. Adem\u00e1s, mediante un mlr se detect\u00f3 un aumento significativo en la capacidad aloestimuladora de las dcs pretratadas con prl, dicho incremento parece ser consecuencia principalmente del aumento en la producci\u00f3n de il12 inducido por prl que a su vez afectar\u00eda la expresi\u00f3n de cd80 y la producci\u00f3n de tnf-alfa e il-1beta.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la prolactina sobre la diferenciaci\u00f3n intrat\u00edmica de rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la prolactina sobre la diferenciaci\u00f3n intrat\u00edmica de rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paz Carolina Carre\u00f1o Palacios <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agustin Gregorio Zapata Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>pedro Garc\u00eda merrad\u00f3n (vocal)<\/li>\n<li>Jorge Martin perez (vocal)<\/li>\n<li>paz carolina Carre\u00f1o palacios (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paz Carolina Carre\u00f1o Palacios La diferenciaci\u00f3n de los timocitos se inicia en la vida fetal y es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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