{"id":19851,"date":"2002-08-11T00:00:00","date_gmt":"2002-08-11T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/catalisis-heterogenea-en-la-sa%c2%adntesis-de-precursores-de-r-2-4-hidroxifenilglicina\/"},"modified":"2002-08-11T00:00:00","modified_gmt":"2002-08-11T00:00:00","slug":"catalisis-heterogenea-en-la-sa%c2%adntesis-de-precursores-de-r-2-4-hidroxifenilglicina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/zaragoza\/catalisis-heterogenea-en-la-sa%c2%adntesis-de-precursores-de-r-2-4-hidroxifenilglicina\/","title":{"rendered":"Cat\u00e1lisis heterog\u00e9nea en la s\u00edntesis de precursores de (r)-2-(4-hidroxifenil)glicina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz L\u00e1zaro Peir\u00f3 <\/strong><\/h2>\n<p>La dl-5-(4-hidroxifenil)hidanto\u00edna es un intermedio importante en la producci\u00f3n enzim\u00e1tica de (r)-2-(4-hidroxifenil)glicina, compuesto usado en la preparaci\u00f3n de f\u00e1rmacos, en particular, de antibi\u00f3ticos beta-lact\u00e1micos, como penicilinas y cefalosporinas semisint\u00e9ticas.  la dl-5-(4-hidroxifenil)hidanto\u00edna se obtiene industrialmente por amidoalquilaci\u00f3n de fenol con urea y \u00e1cido gliox\u00edlico, usando un gran exceso de \u00e1cido mineral concentrado. En esta reacci\u00f3n se obtiene una mezcla con buenos rendimientos de dl-5-(4-hidroxifenil)hidanto\u00edna y dl-5-(2-hidroxifenil)hidanto\u00edna.  otras estrategias relevantes para sintetizar dl-5-(4-hidroxifenil)hidanto\u00edna consisten en llevar a cabo la reacci\u00f3n de s\u00edntesis en dos etapas.  por un lado, en la primera etapa, el \u00e1cido gliox\u00edlico puede reacci\u00f3n con un exceso de urea para producir alanto\u00edna, y en la segunda etapa, la alanto\u00edna reacciona con fenol par dar una mezcla de dl-5-(4-hidroxifenil)hidanto\u00edna y del-5-(2-hidroxifenil)hidanto\u00edna.  otra posibilidad consiste en una primera etapa de s\u00edntesis de 5-hidroxihidanto\u00edna, por ejemplo a partir del \u00e1cido parab\u00e1nico, con una segunda etapa de reacci\u00f3n entre 5-hidroxihidanto\u00edna y fenol, obteni\u00e9ndose una mezcla de dl-5-(4-hidroxifenil)hidanto\u00edna y dl-5-(2-hidroxifenil)hidanto\u00edna.  por otro lado, en una primera etapa, en medio b\u00e1sico, el \u00e1cido gliox\u00edlico puede reaccionar con fenol para dar \u00e1cido p-hidroximand\u00e9lico, y \u00e9ste, en la segunda etapa, reacciona con urea para dar dl-5-(4-hidroxifenil)hidanto\u00edna.  al igual que ocurre en la s\u00edntesis directa, los m\u00e9todos por etapas requieren la utilizaci\u00f3n de un gran exceso de \u00e1cido mineral concentrado.  el planteamiento general de la tesis doctoral consiste en la aplicaci\u00f3n de nuevas metodolog\u00edas, en particular de cat\u00e1lisis heterog\u00e9nea, a la s\u00edntesis de dl-5-(4-hidroxifenil)hidanto\u00edna. El empleo de catalizadores heterog\u00e9neros, comporta una serie de ventajas, como son la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cat\u00e1lisis heterog\u00e9nea en la s\u00edntesis de precursores de (r)-2-(4-hidroxifenil)glicina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cat\u00e1lisis heterog\u00e9nea en la s\u00edntesis de precursores de (r)-2-(4-hidroxifenil)glicina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz L\u00e1zaro Peir\u00f3 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Mayoral Murillo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos \u00e1lvarez ibarra <\/li>\n<li> Hoz ayuso Antonio  de la (vocal)<\/li>\n<li>Carlos Cativiela mar\u00edn (vocal)<\/li>\n<li>Antonio Pallar\u00e9s bayo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz L\u00e1zaro Peir\u00f3 La dl-5-(4-hidroxifenil)hidanto\u00edna es un intermedio importante en la producci\u00f3n enzim\u00e1tica de (r)-2-(4-hidroxifenil)glicina, compuesto usado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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