{"id":19909,"date":"2018-03-09T09:09:03","date_gmt":"2018-03-09T09:09:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-autoanta%c2%adgenos-en-el-sa%c2%adndrome-de-sja%c2%b6gren\/"},"modified":"2018-03-09T09:09:03","modified_gmt":"2018-03-09T09:09:03","slug":"nuevos-autoanta%c2%adgenos-en-el-sa%c2%adndrome-de-sja%c2%b6gren","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/la-laguna\/nuevos-autoanta%c2%adgenos-en-el-sa%c2%adndrome-de-sja%c2%b6gren\/","title":{"rendered":"Nuevos autoant\u00edgenos en el s\u00edndrome de sj\u00c1\u00b6gren"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ivan Alejandro Ferraz Amaro <\/strong><\/h2>\n<p>Tras la obtenci\u00f3n de un suero de una paciente con manifestaciones neurol\u00f3gicas de s\u00edndrome de sj\u00ed\u00b6gren, este fue testado en una genoteca de cerebro humano con el fin de identificar clones de cdna que reaccionaran contra dicho suero, con el prop\u00f3sito de identificar nuevos autoant\u00edgenos en esta enfermedad y, concretamente, en aquellos pacientes con manifestaciones neurol\u00f3gicas. entre los clones de cdna que se obtuvieron hab\u00edan algunos ya conocidos como autoant\u00edgenos en la enfermedad de sj\u00ed\u00b6rgren y otros que no se conoc\u00edan como tales. Se identificaron los clones que sintetizaban las prote\u00ednas tau, wave, prote\u00ednas fijadora de guanina y una prote\u00edna no conocida en humanos que recibi\u00f3 el nombre de prote\u00edna hhesb dada la homolog\u00eda que presentaba frente a una prote\u00edna similar en levadura.  a continuaci\u00f3n se procedi\u00f3 a la s\u00edntesis de prote\u00edna recombinante de las prote\u00ednas tau y hhesb. Escogimos estas prote\u00ednas por la relaci\u00f3n previa de tau con enfermedades neurodegenerativas y hhesb porque era una prote\u00edna desconocida hasta la actualidad. Tras esto, ambas prote\u00ednas fueron testadas mediante western blot en 20 enfermos con manifestaciones neurol\u00f3gicas o de otro tipo de s\u00edndrome de sj\u00ed\u00b6rgren. Las bandas obtenidas en dichos western blot fueron analizadas mediante programa inform\u00e1tico y transformados sus valores en unidades de densidad \u00f3ptica. Se procedi\u00f3 al an\u00e1lisis estad\u00edstico de estos valores tanto en enfermos como sanos para dilucidar si hab\u00eda relaci\u00f3n entre los autoanticuerpos y esta enfermedad.  obtuvimos, en lo referente a la prote\u00edna hhesb una relaci\u00f3n estad\u00edsticamente significativa en la que los enfermos ten\u00edan unos valores de autoanticuerpos inferiores en relaci\u00f3n a los controles. Con respecto a la prote\u00edna tau no obtuvimos resultados significativamente diferentes entre controles y enfermos, siendo los autoant\u00edcuerpos para anti tau prevalentes en poblaci\u00f3n sana y enferma.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos autoant\u00edgenos en el s\u00edndrome de sj\u00c1\u00b6gren<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos autoant\u00edgenos en el s\u00edndrome de sj\u00c1\u00b6gren <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ivan Alejandro Ferraz Amaro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pablo Mart\u00edn Vasallo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Betancor le\u00f3n <\/li>\n<li>Carlos Hern\u00e1ndez calzadilla (vocal)<\/li>\n<li>federico Diaz gonz\u00e1lez (vocal)<\/li>\n<li> Hern\u00e1ndez beriain Jos\u00e9 angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ivan Alejandro Ferraz Amaro Tras la obtenci\u00f3n de un suero de una paciente con manifestaciones neurol\u00f3gicas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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