{"id":19929,"date":"2018-03-09T09:09:04","date_gmt":"2018-03-09T09:09:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-caracterizacion-estructural-de-peptidotecas-conformacionalmente-definidas\/"},"modified":"2018-03-09T09:09:04","modified_gmt":"2018-03-09T09:09:04","slug":"diseno-y-caracterizacion-estructural-de-peptidotecas-conformacionalmente-definidas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-caracterizacion-estructural-de-peptidotecas-conformacionalmente-definidas\/","title":{"rendered":"Dise\u00f1o y caracterizaci\u00f3n estructural de peptidotecas conformacionalmente definidas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pastor Hern\u00e1ndez M. Teresa <\/strong><\/h2>\n<p>Se han dise\u00f1ado dos peptidotecas conformiacionalmente definidas (pcd): la primera de ellas en h\u00e9lice alfa y la segunda en horquilla beta.  la deconvoluci\u00f3n estructural de la pcd en h\u00e9lice alfa, ha proporcionado un conjunto de 12 p\u00e9ptidos con estructura helicoidal. Estos p\u00e9ptidos ha sido utilizados como sistemas modelo para determinar la contribuci\u00f3n de las interacciones de los residuos ubicados en posiciones i, i+3, as\u00ed como los amino\u00e1cidos que participan en las interacciones intermoleculares dando lugar a la formaci\u00f3n de agregados. Adem\u00e1s, a partir de las 160.000 mol\u00e9culas que componen la pcd se ha obtenido, al menos, un p\u00e9ptido que presenta estructura en h\u00e9lice alfa a concentraciones de 1 mm, siendo monom\u00e9rico en condiciones fisiol\u00f3gicas.  la deconvoluci\u00f3n estructural de la pcd en horquilla beta ha generado una colecci\u00f3n de 36 p\u00e9ptidos (mbh) de secuencia definida. La caracterizaci\u00f3n estructural de estos p\u00e9ptidos se ha realizado mediante dicroismo circular y rmn. Los estudios estructurales de los mismos ha puesto de manifiesto que todos ellos presentan estructura en horquilla beta y a partir de estos se ha determinado la contribuci\u00f3n a nivel de los amino\u00e1cidos que m\u00e1s contribuyen en la estabilizaci\u00f3n de esta estructura. De este grupo cabe destacar dos p\u00e9ptidos (mbh#12 y mbh#36) que presentan porcentajes de estructuras superiores al 65% de estructura en disoluci\u00f3n acuosa.  finalmente, se evalu\u00f3 la actividad biol\u00f3gica de la pcd en h\u00e9lice alfa. estas peptidoteca fue ensayada con el objetivo de inhibir parcialmente la formaci\u00f3n de complejo snare. Dicho complejo se halla implicado en la fusi\u00f3n de la membrana de la ves\u00edcula sin\u00e1ptica con la membrana presin\u00e1ptica, siendo necesaria su presencia en la transmisi\u00f3n del impulso nervioso. La hiperactivaci\u00f3n de este proceso es la causa de diversas sintomatolog\u00edas tales como las distonias, el beflaroplato y el estrabismo entre otros. as\u00ed pues, se decidi\u00f3 utiliza<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o y caracterizaci\u00f3n estructural de peptidotecas conformacionalmente definidas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o y caracterizaci\u00f3n estructural de peptidotecas conformacionalmente definidas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pastor Hern\u00e1ndez M. Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Perez Paya<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: concepci\u00f3n Abad manzarino <\/li>\n<li>ernesto Nicolas galindo (vocal)<\/li>\n<li>bernardo Celda mu\u00f1oz (vocal)<\/li>\n<li> Jimenez l\u00f3pez m. angeles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pastor Hern\u00e1ndez M. Teresa Se han dise\u00f1ado dos peptidotecas conformiacionalmente definidas (pcd): la primera de ellas en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[25175,60918,34359,60919,56353,60917],"class_list":["post-19929","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-bernardo-celda-munoz","tag-concepcion-abad-manzarino","tag-enrique-perez-paya","tag-ernesto-nicolas-galindo","tag-jimenez-lopez-m-angeles","tag-pastor-hernandez-m-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19929","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=19929"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/19929\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=19929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=19929"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=19929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}