{"id":19930,"date":"2018-03-09T09:09:04","date_gmt":"2018-03-09T09:09:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelo-experimental-de-sepsis-neumococica-en-raton-inmunocompetente-y-actividad-comparada-de-antimicrobianos-en-administracion-oral\/"},"modified":"2018-03-09T09:09:04","modified_gmt":"2018-03-09T09:09:04","slug":"modelo-experimental-de-sepsis-neumococica-en-raton-inmunocompetente-y-actividad-comparada-de-antimicrobianos-en-administracion-oral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/modelo-experimental-de-sepsis-neumococica-en-raton-inmunocompetente-y-actividad-comparada-de-antimicrobianos-en-administracion-oral\/","title":{"rendered":"Modelo experimental de sepsis neumococica en rat\u00f3n inmunocompetente y actividad comparada de antimicrobianos en administraci\u00f3n oral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miriam Alkorta Gurrutxaga <\/strong><\/h2>\n<p>Se desarroll\u00f3 un modelo experimental de sepsis en rat\u00f3n inmunocompetente para estudiar la actividad de varios antibi\u00f3ticos betalact\u00e1micos y quinolonas orales (amoxicilina, cefuroxima, cefpodoxima, cefaclor, levofloxacino, moxofloxacino y gemifoxacino) frente a distintas cepas de s.Pneumoniae (sp).  las cepas estudiadas fueron: sensible a penicilina; resistente parcial la penicilina; resistente a penicilina; resistente a pinicilina+amoxicilina; sensible a ciprofloxacino; y dos cepas resistentes a ciprofloxacino.  los ratones fueron inoculados intraperitonealmente con la dosis letal m\u00ednima (m\u00ednima dosis de microorganismo con la que mor\u00eda 100% de los ratones inoculados en un plazo m\u00e1ximo de 7 d\u00edas). Para provocar la infecci\u00f3n, debido a que las cepas de neumococo no eran virulentas para el rat\u00f3n se utiliz\u00f3 adyuvante de freund para el estudio de los beta-lact\u00e1micos y mucina para el de las fluoroquinolonas.  tras provocar la infecci\u00f3n se administraron los antibi\u00f3ticos por v\u00eda oral con el fin de calcular la dosis protectiva (dosis de antibi\u00f3tico con la que sobreviv\u00eda el 100% de los ratones infectados en un plazo de 15 d\u00edas). los estudios \u00abin vivo\u00bb se complementaron calculando los par\u00e1metros farmacocin\u00e9ticos y farmacodin\u00e1micos para las dosis protectivas en suero de rat\u00f3n.  todas las cepas de sp fueron tambi\u00e9n estudiadas \u00abin vitro\u00bb: cmi, cmb y curvas de letalidad. Los antibi\u00f3ticos beta-lact\u00e1micos se estudiaron tambi\u00e9n \u00abex vivo\u00bb calculando la actividad inhibitoria y bactericida del suero de voluntarios sanos y de ratones que previamente hab\u00edan tomado los antibi\u00f3ticos a estudio.  en el grupo de los beta-lact\u00e1micos, amoxicilina result\u00f3 el m\u00e1s activo en todos los estudios (\u00abin vitro\u00bb, \u00abin vivo\u00bb y \u00abex vivo\u00bb) seguido de cefpodoxima y por \u00faltimo cefuroxima. Cefaclor se excluy\u00f3 tras los malos resultados obtenidos en las fases iniciales del estudio. Todos los antibi\u00f3ticos resultaron activos con la cepa sensible a pen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelo experimental de sepsis neumococica en rat\u00f3n inmunocompetente y actividad comparada de antimicrobianos en administraci\u00f3n oral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelo experimental de sepsis neumococica en rat\u00f3n inmunocompetente y actividad comparada de antimicrobianos en administraci\u00f3n oral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miriam Alkorta Gurrutxaga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio P\u00e9rez Trallero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Cisterna cancer <\/li>\n<li>lorenzo Aguilar alfaro (vocal)<\/li>\n<li>adela Sanz aguado (vocal)<\/li>\n<li>gustavo Cilla eguiluz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miriam Alkorta Gurrutxaga Se desarroll\u00f3 un modelo experimental de sepsis en rat\u00f3n inmunocompetente para estudiar la actividad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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