{"id":1997,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/efectos-de-los-agonistas-opioides-mu-delta-y-kappa-en-miocardio-auricular-humano\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"efectos-de-los-agonistas-opioides-mu-delta-y-kappa-en-miocardio-auricular-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-los-agonistas-opioides-mu-delta-y-kappa-en-miocardio-auricular-humano\/","title":{"rendered":"Efectos de los agonistas opioides mu, delta y kappa en miocardio auricular humano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisca Mar\u00eda Llobell Sala <\/strong><\/h2>\n<p>Nuestros objetivos fueron estudiar el mecanismo de accion implicado en el efecto cardiaco directo que presentan los agonistas opioides morfina, damgo, dpdpe y u-50 488h en tiras de miocardio auricular humano procedentes de grupo 1: pacientes sin insuficiencia cardiaca manifiesta; y grupo 2: pacientes con insuficiencia cardiaca (ic) manifiesta. Para ello se estudiaron 70 pacientes programados para cirugia cardiaca bajo circulacion extracorporea (cec) separados en 2 grupos de estudio. De estos se obtuvo la preparacion correspondiente al borde libre de la auricula derecha humana y se realizaron curvas dosis-respuesta acumulativas con los farmacos agonistas antes descritos y tambien con los farmacos antagonistas opioides: naloxona, naltrindol y norbinaltorfimina (nor-bni). Para evaluar si habia participacion de receptores opoioides (ro) se realizaron curvas dosis-respuesta de agonista selectivo en presencia de una concentracion preestablecida de antagonista selectivo.  asimismo, valoramos la respuesta obtenida entre ambos grupos por ver si la presencia de ic modificaba la respuesta a dichos farmacos. Nuestras conclusiones fueron que: 1.-Los ro no estan implicados en el efecto de los agonistas opioides. 2.- La interaccion entre agonistas opioides-sistema b-adrenergico podria ser el mec.Responsable.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de los agonistas opioides mu, delta y kappa en miocardio auricular humano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de los agonistas opioides mu, delta y kappa en miocardio auricular humano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisca Mar\u00eda Llobell Sala <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Luisa Laorden Carrasco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Victoria Milan\u00e9s Maquil\u00f3n <\/li>\n<li> Vargas Alvarez-castellanos M. Luisa (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Palanca San Francisco (vocal)<\/li>\n<li>Josep Torrent Farnell (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisca Mar\u00eda Llobell Sala Nuestros objetivos fueron estudiar el mecanismo de accion implicado en el efecto cardiaco [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,483,8235],"tags":[8547,8550,8551,8548,8481,8549],"class_list":["post-1997","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-mecanismos-de-accion-de-los-farmacos","category-murcia","tag-francisca-maria-llobell-sala","tag-jose-maria-palanca-san-francisco","tag-josep-torrent-farnell","tag-maria-luisa-laorden-carrasco","tag-maria-victoria-milanes-maquilon","tag-vargas-alvarez-castellanos-m-luisa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/1997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=1997"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/1997\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=1997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=1997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=1997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}