{"id":19976,"date":"2018-03-09T09:09:09","date_gmt":"2018-03-09T09:09:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tramadol-estudio-sobre-la-enantioselectividad-de-su-farmacocinetica\/"},"modified":"2018-03-09T09:09:09","modified_gmt":"2018-03-09T09:09:09","slug":"tramadol-estudio-sobre-la-enantioselectividad-de-su-farmacocinetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/tramadol-estudio-sobre-la-enantioselectividad-de-su-farmacocinetica\/","title":{"rendered":"Tramadol: estudio sobre la enantioselectividad de su farmacocin\u00e9tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Emilio Garc\u00eda Quetglas <\/strong><\/h2>\n<p>Tramadol es un analg\u00e9sico de acci\u00f3n central que combina el efecto analg\u00e9sico opioide y el de los inhibidores de recaptaci\u00f3n de monoaminas. Estructuralmente, es una mol\u00e9cula comercializada como una mezcla rac\u00e9mica de los is\u00f3meros 1r,2r y 1s,2s. Se metaboliza en el h\u00edgado a trav\u00e9s de 2 v\u00edas metab\u00f3licas originando 2 metabolitos primarios: o-desmetiltramadol y n-desmetiltramadol.  este proceso est\u00e1 catalizado por varias ioenzimas del sistema cyp450, tal como han demostrado recientes estudios \u00abin vitro\u00bb y posee propiedades enantioselectivas. una de ellas, la cyp2d6 o esparte\u00edna\/debrisoquina oxigenasa, responsable de la transformaci\u00f3n de tramadol a o-desmetiltramadol, es una de las isoenzimas con mayor polimorfismo asociado a trascendencia cl\u00ednica. La otra v\u00eda metab\u00f3lica, n-desmetilaci\u00f3n no ha sido caracterizada con anterioridad ni en animales ni en seres humanos. Los objetivos del presente trabajo fueron la definici\u00f3n de los par\u00e1metros farmacocin\u00e9ticos de los enanti\u00f3meros de tramadol y sus metabolitos primarios tras la administraci\u00f3n oral de la forma rac\u00e9mica a voluntarios sanos, as\u00ed como la utilizaci\u00f3n de diversos ratios obtenidos con par\u00e1metros farmacocin\u00e9ticos d eo-desmetiltramadol como estimadores del fenotipo metabolizador debido a la elevada correlaci\u00f3n entre la o-desmetilaci\u00f3n de tramadol y la oxidaci\u00f3n de esparte\u00edna. Los par\u00e1metros farmacocin\u00e9ticos fueron estimados mediante un modelo de ajuste simult\u00e1neo utilizando el programa winnon lin.  el estudio de los par\u00e1metros farmacocin\u00e9ticos de los enanti\u00f3meros de tramadol demuestra que la absorci\u00f3n y eliminaci\u00f3n de tramadol es enantioselectiva tras su administraci\u00f3n por v\u00eda oral. La formaci\u00f3n de o-desmetiltramadol es m\u00e1s r\u00e1pida tras la administraci\u00f3n del f\u00e1rmaco oral, alcanzando valores imilares de cmax, debido a la saturaci\u00f3n que se observa en esta v\u00eda metab\u00f3lica tras la administraci\u00f3n del f\u00e1rmaco por v\u00eda endovenosa. Sin embargo, tambi\u00e9n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tramadol: estudio sobre la enantioselectividad de su farmacocin\u00e9tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tramadol: estudio sobre la enantioselectividad de su farmacocin\u00e9tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Emilio Garc\u00eda Quetglas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Azanza Perea Jos\u00e9 Ram\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Rio zambrano joaqu\u00edn del <\/li>\n<li>Juan  Luis Tamargo men\u00e9ndez (vocal)<\/li>\n<li>francesc Jane carrencia (vocal)<\/li>\n<li>Francisco Carrascosa moreno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Emilio Garc\u00eda Quetglas Tramadol es un analg\u00e9sico de acci\u00f3n central que combina el efecto analg\u00e9sico opioide y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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