{"id":19995,"date":"2018-03-09T09:09:10","date_gmt":"2018-03-09T09:09:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-de-la-expresion-de-los-genes-de-biosa%c2%adntesis-de-cefamicina-c-en-streptomyces-clavuligerus-por-la-protea%c2%adna-ccar\/"},"modified":"2018-03-09T09:09:10","modified_gmt":"2018-03-09T09:09:10","slug":"control-de-la-expresion-de-los-genes-de-biosa%c2%adntesis-de-cefamicina-c-en-streptomyces-clavuligerus-por-la-protea%c2%adna-ccar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/leon\/control-de-la-expresion-de-los-genes-de-biosa%c2%adntesis-de-cefamicina-c-en-streptomyces-clavuligerus-por-la-protea%c2%adna-ccar\/","title":{"rendered":"Control de la expresi\u00f3n de los genes de bios\u00edntesis de cefamicina c en streptomyces clavuligerus por la prote\u00edna ccar"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irene Santamarta Hern\u00e1ndez <\/strong><\/h2>\n<p>El gen ccar se ha descrito como regulador positivo de la bios\u00edntesis de cefamicina c y \u00e1cido clavul\u00e1nico en streptomyces clavuligerus (p\u00e9rez-llarena y col., 1997). Perteneciente a la familia de prote\u00ednas sarp, que controlan la bios\u00edntesis de antibi\u00f3ticos en varias especies del mismo g\u00e9nero, la prote\u00edna ccar codificada en este gen, presenta homolog\u00eda con reguladores espec\u00edficos de la bios\u00edntesis de antibi\u00f3ticos en otras especies de estreptomicetos, los cuales realizan su funci\u00f3n activadora mediante uniones espec\u00edficas a regiones promotoras de las agrupaciones biosint\u00e9ticas correspondientes (arias y col., 1999; stutzman-engwall y col., 1992).  el trabajo realizado supone la caracterizaci\u00f3n de esta actividad reguladora, a trav\u00e9s de la purificaci\u00f3n de la prote\u00edna ccar y siguientes estudios in vitro e in vivo. En los estudios in vitro, se han llevado a cabo experimentos de uni\u00f3n adn-prote\u00ednas y posterior resoluci\u00f3n en geles no desnaturalizantes (t\u00e9cnicas emsa) determin\u00e1ndose la uni\u00f3n de la prote\u00edna a dos regiones promotoras de la agrupaci\u00f3n g\u00e9nica de bios\u00edntesis de cefamicina c: el propio promotor g\u00e9nico de ccar y una regi\u00f3n de actividad promotora bidireccional situada entre los genes biosint\u00e9ticos cefd y cmci. No se han podido detectar uniones con las regiones promotoras analizadas pertenecientes a la agrupaci\u00f3n de bios\u00edntesis de \u00e1cido clavul\u00e1nico, lo que no descarta una regulaci\u00f3n directa de ccar sobre esta ruta biosint\u00e9tica, aunque tambi\u00e9n podr\u00eda ejercer su regulaci\u00f3n a trav\u00e9s de un factor transcripciona adicional.  el car\u00e1cter activador de las uniones detectadas entre ccar y las regiones promotoras de ccar y cefd-cmci, se ha determinado a trav\u00e9s de los ensayos in vivo realizados mediante fusiones transcripcionales de los promotores analizados al gen testigo xyle. A trav\u00e9s de estos ensayos se concreta una autorregulaci\u00f3n positiva ejercida por ccar sobre la transcripci\u00f3n del gen que la codifica<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Control de la expresi\u00f3n de los genes de bios\u00edntesis de cefamicina c en streptomyces clavuligerus por la prote\u00edna ccar<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Control de la expresi\u00f3n de los genes de bios\u00edntesis de cefamicina c en streptomyces clavuligerus por la prote\u00edna ccar <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irene Santamarta Hern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Paloma Liras Pad\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Francisco Mart\u00edn mart\u00edn <\/li>\n<li>gloria Blanco blanco (vocal)<\/li>\n<li>Antonio Jimenez-Martinez (vocal)<\/li>\n<li>Jos\u00e9 Luis Barredo fuente (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irene Santamarta Hern\u00e1ndez El gen ccar se ha descrito como regulador positivo de la bios\u00edntesis de cefamicina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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