{"id":20000,"date":"2018-03-09T09:09:11","date_gmt":"2018-03-09T09:09:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-galenico-de-microemulsiones-para-la-administracion-transdermica-de-nifedipino\/"},"modified":"2018-03-09T09:09:11","modified_gmt":"2018-03-09T09:09:11","slug":"desarrollo-galenico-de-microemulsiones-para-la-administracion-transdermica-de-nifedipino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-galenico-de-microemulsiones-para-la-administracion-transdermica-de-nifedipino\/","title":{"rendered":"Desarrollo gal\u00e9nico de microemulsiones para la administraci\u00f3n transdermica de nifedipino"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Castro Moreno <\/strong><\/h2>\n<p>En el presente trabajo se ha desarrollado una formulaci\u00f3n de nifedipino completamente nueva, jam\u00e1s descrita en la bibliograf\u00eda, para la administraci\u00f3n trasnd\u00e9rmica que mejore las caracter\u00edsticas terap\u00e9uticas del principio activo respecto a las formas farmac\u00e9uticas convencionales existentes (evitar efecto del primer paso hep\u00e1tico, mantener constantes niveles plasm\u00e1ticos, reducir efectos adversos y mejorar el cumplimiento posol\u00f3gico).  en primer lugar, se procedi\u00f3 a estudiar y caracterizar el nifedipino de manera detallada, para lo cual fue necesario la validaci\u00f3n de m\u00e9todos anal\u00edticos cuantitativos (hplc, espectrofotometr\u00eda uv\/vis, espectrofotometr\u00eda de primera derivada uv\/vis) y la puesta a punto una serie de t\u00e9cncias anal\u00edticas cualitativas (tlc, espectroscop\u00eda de absorci\u00f3n infrarroja y dsc entre otras). en este estudio del principio activo se determinan una serie de par\u00e1metros de vital importancia para el desarrollo de las microemulsiones m\u00faltiples. entre estos par\u00e1metros destacan el coeficiente de reparto octanol\/agua, solubilidad en medio acuoso en funci\u00f3n del ph, en medios lip\u00f3filos, solventes y mezclas de solventes y las condiciones de estabilidad en funci\u00f3n de la temperatura y de distintas fuentes de irradiaci\u00f3n.  en segundo lugar, se desarrollaron las microemulsiones m\u00faltiples o\/a\/o de nifedipino en dos etapas;  1\u00aa) dise\u00f1o de la microemulsi\u00f3n primaria o\/a, que constituye la fase interna de la microemulsi\u00f3n m\u00faltiple, en funci\u00f3n de distintos tensioactivos y cotensioactivos. Se seleccion\u00f3 aquella microemulsi\u00f3n primaria o\/a que incorpora el mayor contenido en fase interna y por lo tanto de nifedipino, con el menor porcentaje tensioactivo\/cotensioactivo requerido.  2\u00aa) dise\u00f1o de las microemulsiones m\u00faltiples o\/a\/o utilizando brij 96 como tensioactivo y peg 400 y pg como contesioactivos. Se estudi\u00f3 la reolog\u00eda, viscosidad y tama\u00f1o de gota en funci\u00f3n de diferentes par\u00e1metros. Se seleccion\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo gal\u00e9nico de microemulsiones para la administraci\u00f3n transdermica de nifedipino<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo gal\u00e9nico de microemulsiones para la administraci\u00f3n transdermica de nifedipino <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Castro Moreno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Lastres Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda de la paloma Ballesteros papantonakis <\/li>\n<li>Jos\u00e9 Blanco m\u00e9ndez (vocal)<\/li>\n<li>ram\u00f3n Mart\u00ednez pacheco (vocal)<\/li>\n<li>marina Herraez dominguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Castro Moreno En el presente trabajo se ha desarrollado una formulaci\u00f3n de nifedipino completamente nueva, jam\u00e1s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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