{"id":20030,"date":"2018-03-09T09:09:13","date_gmt":"2018-03-09T09:09:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/agentes-insulinotropicos-in-vivo-potencial-uso-terapeutico-en-la-diabetes-tipo-2\/"},"modified":"2018-03-09T09:09:13","modified_gmt":"2018-03-09T09:09:13","slug":"agentes-insulinotropicos-in-vivo-potencial-uso-terapeutico-en-la-diabetes-tipo-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/agentes-insulinotropicos-in-vivo-potencial-uso-terapeutico-en-la-diabetes-tipo-2\/","title":{"rendered":"Agentes insulinotr\u00f3picos in vivo: potencial uso terape\u00fatico en la diabetes tipo 2"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Cancelas Navia <\/strong><\/h2>\n<p>Es conocido que en condiciones fisiol\u00f3gicas, la secreci\u00f3n y bios\u00edntesis de insulina est\u00e1n reguladas por la concentraci\u00f3n de nutrientes circulantes, principalmente la d-glucosa. Y que en la diabetes no dependiente de insulina, o tipo 2, la c\u00e9lula beta pancre\u00e1tica se manifiesta parcialmente insensible al est\u00edmulo del az\u00facar.  la existencia de nutrientes -\u00e9steres de monosac\u00e1ridos y de metabolitos no gluc\u00eddicos- capaces de atravesar la membrana plasm\u00e1tica, sin la intervenci\u00f3n de un sistema espec\u00edfico de transporte, que permiten a la c\u00e9lula beta diab\u00e9tica mantener su capacidad secretora, y el hecho de que determinados agentes, como el glp-1 -p\u00e9ptido intestinal insulinotr\u00f3pico, antidiab\u00e9tico y con efectos insulino-mim\u00e9tricos sobre el metabolismo de la glucosa en tejidos extrapancre\u00e1ticos-, necesiten de la presencia de glucosa para ejercer su acci\u00f3n insulinotr\u00f3pica, nos condujo a estudiar el efecto in vivo de algunos de estos nutrientes sobre la respuesta secretora de la c\u00e9lula beta al glp-1, y a p\u00e9ptidos, estructural y funcionalmente, relacionados con \u00e9l -las exendinas-. tambi\u00e9n exploramos el efecto de alguno de los \u00e9steres sobre el metabolismo de la glucosa en el hepatocito de la rata, as\u00ed como alg\u00fan posible efecto del glp-1 sobre el metabolismo de la glucosa a nivel perif\u00e9rico.  observando que, tanto el \u00e9ster pentaacetato de d-glucosa, como determinados \u00e9steres no gluc\u00eddicos -el metil piruvato, el dimetil glutamato o el dimetil succinato-permit\u00edan al glp-1, y a otros agentes secretagogos de insulina como la exendina-4 expresar su potencial.  con lo que la utilizaci\u00f3n conjunta de ambos, \u00e9steres y p\u00e9ptidos secretagogos, se constituye en prometedora herramienta para el tratamiento de la diabetes tipo 2.  por su parte, la ex(9-39), suprim\u00eda la respuesta de la c\u00e9lula beta al glp-1, y reduc\u00eda la acci\u00f3n hipoglucemiante del p\u00e9ptido, sin modificar la respuesta del p\u00e1ncreas a nutrientes circulantes, por l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Agentes insulinotr\u00f3picos in vivo: potencial uso terape\u00fatico en la diabetes tipo 2<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Agentes insulinotr\u00f3picos in vivo: potencial uso terape\u00fatico en la diabetes tipo 2 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Cancelas Navia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Valverde Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Bl\u00e1zquez fern\u00e1ndez <\/li>\n<li>Luisa Villanueva-pe\u00f1acarrillo m. (vocal)<\/li>\n<li>Jos\u00e9 enrique Campillo \u00e1lvarez (vocal)<\/li>\n<li>david Vicent l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Cancelas Navia Es conocido que en condiciones fisiol\u00f3gicas, la secreci\u00f3n y bios\u00edntesis de insulina est\u00e1n reguladas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[61160,3180,5536,61159,1743,14889],"class_list":["post-20030","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-david-vicent-lopez","tag-enrique-blazquez-fernandez","tag-isabel-valverde-alonso","tag-jesus-cancelas-navia","tag-jose-enrique-campillo-alvarez","tag-luisa-villanueva-penacarrillo-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=20030"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20030\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=20030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=20030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=20030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}