{"id":20089,"date":"2018-03-09T09:09:18","date_gmt":"2018-03-09T09:09:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-y-caracterizacion-de-la-s-adenosilmetionina-sintetasa-de-leishmania-donovani\/"},"modified":"2018-03-09T09:09:18","modified_gmt":"2018-03-09T09:09:18","slug":"identificacion-y-caracterizacion-de-la-s-adenosilmetionina-sintetasa-de-leishmania-donovani","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/leon\/identificacion-y-caracterizacion-de-la-s-adenosilmetionina-sintetasa-de-leishmania-donovani\/","title":{"rendered":"Identificaci\u00f3n y caracterizaci\u00f3n de la s-adenosilmetionina sintetasa de leishmania donovani"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yolanda P\u00e9rez Pertejo <\/strong><\/h2>\n<p>La metionina adenosiltransferasa (mat), anteriormente conocida como s-adenosilmetionina sintetasa, cataliza la s\u00edntesis de s-adenosilmetionina (adomet), utilizando atp y l-metionina como sustratos. La adomet es una mol\u00e9cular clave en el metabolismo celular, pues act\u00faa como donante de grupos metilo en el 90% de las reacciones de transmetilaci\u00f3n de la c\u00e9lula y una vez descarboxilada cede su grupo amino propilo para la s\u00edntesis de poliaminas.  en este trabajo hemos identificado y caracterizado la mat de leishmania donovani. El gen que codifica para dicha enzima est\u00e1 constituido por una secuencia de nucle\u00f3tidos de 1179 pb y genera una polip\u00e9ptido de 392 amino\u00e1cidos con un peso molecular te\u00f3rico de 43 kda.  tras la purificaci\u00f3n de esta prote\u00edna, procedimos a su caracterizaci\u00f3n enzim\u00e1tica y al estudio mutacional de los amino\u00e1cidos implicados tanto en la cat\u00e1lisis como en el mantenimiento de la estructura.  finalmente, realizamos la expresi\u00f3n hom\u00f3loga de la mat en promastigotes de l.Donovani y observamos, entre otras cosas, que los promastigotes son capaces de expulsar, por un mecanismo desconocido, el exceso de adomet que les resulta perjudicial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n y caracterizaci\u00f3n de la s-adenosilmetionina sintetasa de leishmania donovani<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n y caracterizaci\u00f3n de la s-adenosilmetionina sintetasa de leishmania donovani <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yolanda P\u00e9rez Pertejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Ordo\u00f1ez Escudero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Chinchetru manero Miguel angel <\/li>\n<li>Luis Rivas l\u00f3pez (vocal)<\/li>\n<li> Requena rolaina Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li> Pajares taranc\u00f3n m. \u00e1ngeles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yolanda P\u00e9rez Pertejo La metionina adenosiltransferasa (mat), anteriormente conocida como s-adenosilmetionina sintetasa, cataliza la s\u00edntesis de s-adenosilmetionina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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