{"id":20129,"date":"2018-03-09T09:09:21","date_gmt":"2018-03-09T09:09:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-mediante-rt-pcr-de-la-presencia-de-psa-y-o-psma-en-ganglios-linfaticos-histologicamente-negativos-en-pacientes-con-adenocarcinoma-de-prostata-localizado-valor-pronostico\/"},"modified":"2018-03-09T09:09:21","modified_gmt":"2018-03-09T09:09:21","slug":"determinacion-mediante-rt-pcr-de-la-presencia-de-psa-y-o-psma-en-ganglios-linfaticos-histologicamente-negativos-en-pacientes-con-adenocarcinoma-de-prostata-localizado-valor-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/determinacion-mediante-rt-pcr-de-la-presencia-de-psa-y-o-psma-en-ganglios-linfaticos-histologicamente-negativos-en-pacientes-con-adenocarcinoma-de-prostata-localizado-valor-pronostico\/","title":{"rendered":"Determinaci\u00f3n mediante rt-pcr de la presencia de psa y\/o psma en ganglios linf\u00e1ticos histol\u00f3gicamente negativos en pacientes con adenocarcinoma de pr\u00f3stata localizado. valor pron\u00f3stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gonzalo Sanz P\u00e9rez <\/strong><\/h2>\n<p>Objetivos  realizar un trabajo prospectivo que incluya a nuestros pacientes intervenidos de prostatectom\u00eda radical debido a c\u00e1ncer de pr\u00f3stata clinicamente localizado y estudiar las variables cl\u00ednico, patol\u00f3gicas y biol\u00f3gicas de nuestra serie.  realizar linfadenectom\u00eda a todos los pacientes previa a la linfadenectom\u00eda y en todos los casos en los que la anatom\u00eda patol\u00f3gica informe como no afectaci\u00f3n ganglionar, realizar rt-pcr para detectar expresi\u00f3n de psa y psma.  correlacionar los datos cl\u00ednicos, patol\u00f3gicos y biol\u00f3gicos as\u00ed como la presencia de progresi\u00f3n bioqu\u00edmica con la expresi\u00f3n en ganglio linf\u00e1tico de psa y\/o psma mediante rt-pcr.  material y m\u00e9todos  estudio prospectivo de 67 pacientes en los que se realiza linfadenectom\u00eda iliobturatriz previa a la prostatectom\u00eda radical. Se excluyen del estudio los pacientes en tratamiento neoadyuvante y aquellos que presetan afectaci\u00f3n de ganglios linf\u00e1ticos en la pieza de linfadenectom\u00eda. Se estudian las variables edad, psa, gleason de la biopsia y de la pieza de prostatectom\u00eda radical, estadio cl\u00ednico y patol\u00f3gico, expresi\u00f3n de ki 67 y p53 en la pieza de prostatectom\u00eda radical, afectaci\u00f3n de m\u00e1rgenes quir\u00fargicos de la pieza y presencia  \u00f3 no de progresion bioqu\u00edmica.  se realiza determinaci\u00f3n de psa y psma mediante rt-pcr en un cuarto de uno de los ganglios iliobturatrices de cada paciente.  resultados  despu\u00e9s de 27 meses de mediana de seguimientos encontramos que el 68% de los pacientes se encuentran vivos y libres de progresi\u00f3n bioqu\u00edmica. Un 57% de los pacientes presetan enfermedad pt2 y un 58% de los pacientes m\u00e1rgenes negativos. La determinaci\u00f3n de psma mediante rt-pcr no demostr\u00f3 relaci\u00f3n con la cantidad de psa gleason de la biopsia ni de la pieza, estadio patol\u00f3gico \u00f3 presencia de afectaci\u00f3n de los m\u00e1rgenes quir\u00fargicos ni existencia de progresi\u00f3n bioqu\u00edmica. Encontramos relaci\u00f3n entre la expresi\u00f3n en ganglio linf\u00e1tico de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinaci\u00f3n mediante rt-pcr de la presencia de psa y\/o psma en ganglios linf\u00e1ticos histol\u00f3gicamente negativos en pacientes con adenocarcinoma de pr\u00f3stata localizado. valor pron\u00f3stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinaci\u00f3n mediante rt-pcr de la presencia de psa y\/o psma en ganglios linf\u00e1ticos histol\u00f3gicamente negativos en pacientes con adenocarcinoma de pr\u00f3stata localizado. valor pron\u00f3stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gonzalo Sanz P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Rosell Costa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis angel Rioja sanz <\/li>\n<li>federico Rodriguez rubio cortadellas (vocal)<\/li>\n<li>Fernando Arocena lanz (vocal)<\/li>\n<li>enrique De \u00e1lava casado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalo Sanz P\u00e9rez Objetivos realizar un trabajo prospectivo que incluya a nuestros pacientes intervenidos de prostatectom\u00eda radical 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