{"id":20140,"date":"2018-03-09T09:09:22","date_gmt":"2018-03-09T09:09:22","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-clopidogrel-sobre-la-retinopata%c2%ada-diabetica-experimental\/"},"modified":"2018-03-09T09:09:22","modified_gmt":"2018-03-09T09:09:22","slug":"efecto-de-clopidogrel-sobre-la-retinopata%c2%ada-diabetica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/efecto-de-clopidogrel-sobre-la-retinopata%c2%ada-diabetica-experimental\/","title":{"rendered":"Efecto de clopidogrel sobre la retinopat\u00edadiab\u00e9tica experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mart\u00ednez Cerd\u00e1n Eva M. <\/strong><\/h2>\n<p>El inter\u00e9s de la retinopat\u00eda diab\u00e9tica no s\u00f3lo se centra en su alta frecuencia, sino en que constituye la primera causa de ceguera en el mundo industrializado. debido a ello se est\u00e1 continuamente investigando sobre las posibles causas de esta complicaci\u00f3n vascular, as\u00ed como el modo de evitarla, para lo cual se est\u00e1n utilizando f\u00e1rmacos antiagregantes plaquetarios ya que se ha visto que existe relaci\u00f3n entre funcionalismo plaquetario, y desarrollo y evoluci\u00f3n de las lesiones retinianas. Tradicionalmente el \u00e1cido acetilsalic\u00edlico (aas) ha sido el agente antiplaquetario mayormente utilizado para la prevenci\u00f3n de los eventos isqu\u00e9micos arteriales, aunque recientemente se ha descrito que \u00e9ste presenta un menor efecto en la poblaci\u00f3n diab\u00e9tica que en la no diab\u00e9tica.  como consecuencia de ello el objetivo de este trabajo se centr\u00f3 en estudiar el posible efecto de clopidogrel a nivel de la retinopat\u00eda diab\u00e9tica experimental, f\u00e1rmaco antiagregante plaquetario de reciente incorporaci\u00f3n, compar\u00e1ndolo con su cong\u00e9nere ticlopidina, el cual lleva m\u00e1s tiempo comercializado pero a su vez presenta m\u00e1s efectos secundarios, y es menos potente. Para realizar dicho estudio se tom\u00f3 al aas como f\u00e1rmaco control por conocer parte del comportamiento de \u00e9ste ante la retinopat\u00eda diab\u00e9tica.  la metodolog\u00eda seguida fue la siguiente: la diabetes se reprodujo en animales de experimentaci\u00f3n (ratas wistar adulta) mediante inyecci\u00f3n de streptozotocina, reproduciendo la diabetes mellitus insulino-dependiente (tipo i) del humano. dichas ratas fueron tratadas con aas, ticlopidina y clopidogrel a distintas concentraciones.  tras tres meses de evoluci\u00f3n de diabetes (existiendo en este periodo una clara isquemia reitiniana) con o sin tratamiento farmacol\u00f3gico, dichas ratas fueron sacrificadas realiz\u00e1ndose en todas ellas el siguiente estudio:  a,- estudio del funcionalismo plaquetario mediante t\u00e9cnica de agregaci\u00f3n plaquetario, y medi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de clopidogrel sobre la retinopat\u00edadiab\u00e9tica experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de clopidogrel sobre la retinopat\u00edadiab\u00e9tica experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mart\u00ednez Cerd\u00e1n Eva M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Pedro De La Cruz Cort\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Jim\u00e9nez mart\u00edn <\/li>\n<li>julio Juan G\u00e1lvez peralta (vocal)<\/li>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez correa (vocal)<\/li>\n<li>Ana Solano Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mart\u00ednez Cerd\u00e1n Eva M. El inter\u00e9s de la retinopat\u00eda diab\u00e9tica no s\u00f3lo se centra en su alta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7834],"tags":[61422,24766,21763,7864,39855,61421],"class_list":["post-20140","post","type-post","status-publish","format-standard","hentry","category-malaga","tag-ana-solano-garcia","tag-jose-antonio-gonzalez-correa","tag-jose-jimenez-martin","tag-jose-pedro-de-la-cruz-cortes","tag-julio-juan-galvez-peralta","tag-Martinez-cerdan-eva-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20140","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=20140"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20140\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=20140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=20140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=20140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}