{"id":20141,"date":"2018-03-09T09:09:22","date_gmt":"2018-03-09T09:09:22","guid":{"rendered":""},"modified":"2018-03-09T09:09:22","modified_gmt":"2018-03-09T09:09:22","slug":"endocarditis-experimental-por-enterococcus-faecium-multirresistente-analisis-de-la-eficacia-del-farmaco-quinupristina-dalfopristina-solo-o-en-combinacion-con-gentamicina-teicoplanina-imipenem-o-lev","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/endocarditis-experimental-por-enterococcus-faecium-multirresistente-analisis-de-la-eficacia-del-farmaco-quinupristina-dalfopristina-solo-o-en-combinacion-con-gentamicina-teicoplanina-imipenem-o-lev\/","title":{"rendered":"Endocarditis experimental por enterococcus faecium multirresistente. an\u00e1lisis de la eficacia del f\u00e1rmaco quinupristina-dalfopristina solo o en combinaci\u00f3n con gentamicina, teicoplanina, imipenem o levofloxacino"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jer\u00f3nimo P\u00e9rez Salmer\u00f3n <\/strong><\/h2>\n<p>El objetivo principal del presente estudio fue comparar la eficacia terap\u00e9utica in vitro de quinupristina-dalfopristina (qd) sola o combinada con gentamicina, teicoplanina, impipenen o levofloxacino, mediante pautas antibi\u00f3ticas de 5 d\u00edas, en un modelo de endocarditis experimental en conejos por enterococcus faecium multirresistente. Igualmente se procedi\u00f3 al estudio in vitro mediante curvas de letalidad bacteriana buscando fen\u00f3menos de sinergia para las combinaciones que mostraran mejor comportamiento in vivo.  fueron analizados un total de 110 conejos de la raza new zealand, de los que finalmente, tras la exclusi\u00f3n de 30, fueron incluidos 80. La sensibilidad de la cepa empleada frente a los antibi\u00f3ticos utilizados fue: intermedio para qd, resistente frente a teicoplanina e imipenem, sensible frente a levofloxacino y no encontramos resistencia de alto nivel frente a gentamicina.  para la valoraci\u00f3n de la respuesta terap\u00e9utica se utiliz\u00f3 como par\u00ed\u00a0metro la concentraci\u00f3n bacteriana en las vegetaciones cardiacas, expresada como log10 de las unidades formadoras de colonias por gramo (ufc\/g).  los resultados in vivo fueron: grupo control 9,49; qd en monoterapia 7,31; qd + gentamicina 7,16; qd + teicoplanina 7,06; qd + imipenem 4,38 y qd + levofloxacino 4,04.  todos los grupos redujeron los niveles de ufc\/g,, de manera estad\u00edsticamente significativa, respecto del grupo control.  no se encontraron diferencias al comparar los grupos qd en monoterapia, qd + gentamicina y qd + teicoplanina.  los grupos qd + imipenen y qd + levofloxacino no mostraron diferencias entre ellos y fueron los m\u00e1s eficaces en reducir el n\u00famero de ufc\/g de vegetaci\u00f3n cardiaca en nuestro modelo experimental.  las curvas de letalidad bacteriana efectuadas para qd e imipenem o levofloxacino no mostraron fen\u00f3menos de sinergia in vitro.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Endocarditis experimental por enterococcus faecium multirresistente. an\u00e1lisis de la eficacia del f\u00e1rmaco quinupristina-dalfopristina solo o en combinaci\u00f3n con gentamicina, teicoplanina, imipenem o levofloxacino<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Endocarditis experimental por enterococcus faecium multirresistente. an\u00e1lisis de la eficacia del f\u00e1rmaco quinupristina-dalfopristina solo o en combinaci\u00f3n con gentamicina, teicoplanina, imipenem o levofloxacino <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jer\u00f3nimo P\u00e9rez Salmer\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Segovia Hern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li>joaquin G\u00f3mez g\u00f3mez (vocal)<\/li>\n<li>Juan  Antonio Ruiperez abizanda (vocal)<\/li>\n<li>Juan  Luis Mu\u00f1oz bellido (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jer\u00f3nimo P\u00e9rez Salmer\u00f3n El objetivo principal del presente estudio fue comparar la eficacia terap\u00e9utica in vitro de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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