{"id":20159,"date":"2018-03-09T09:09:24","date_gmt":"2018-03-09T09:09:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-in-vitro-e-in-vivo-de-elementos-de-la-va%c2%ada-de-mapk-erk-jnk-y-mkp-1-cl100-en-la-carcinogenesis-pulmonar\/"},"modified":"2018-03-09T09:09:24","modified_gmt":"2018-03-09T09:09:24","slug":"estudio-in-vitro-e-in-vivo-de-elementos-de-la-va%c2%ada-de-mapk-erk-jnk-y-mkp-1-cl100-en-la-carcinogenesis-pulmonar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/estudio-in-vitro-e-in-vivo-de-elementos-de-la-va%c2%ada-de-mapk-erk-jnk-y-mkp-1-cl100-en-la-carcinogenesis-pulmonar\/","title":{"rendered":"Estudio in vitro e in vivo de elementos de la v\u00edade mapk (erk, jnk y mkp-1\/cl100) en la carcinog\u00e9nesis pulmonar"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvestre Vicent Cambra <\/strong><\/h2>\n<p>En este estudio evaluamos el papel de mkp-1\/cl100 y de las mapk, erk y jnk, en el c\u00e1ncer de pulm\u00f3n.  estudiamos la expresi\u00f3n de mkp-1\/cl100 y el estado de activaci\u00f3n de estas mapk en 18 l\u00edneas celulares epiteliales de carcinoma de pulm\u00f3n (11 de cnmp y 7 de cmp) y en c\u00e9lulas del epitelio bronquial normal. Adem\u00e1s, estudiamos un modelo  de carcinog\u00e9nesis pulmonar perif\u00e9rica de rata instilada con s\u00edlice y muestras cl\u00ednicas (121 tumores de pulm\u00f3n 113 correspondientes a cnmp y 9 a cmp). Al analizar las l\u00edneas celulares observamos que los niveles de expresi\u00f3n del mrna y de la prote\u00edna de cl100\/mkp-1 son mayores en la l\u00edneas celulares correspondientes a cnmp que a las de cmp. Adem\u00e1s, encontramos activaci\u00f3n de erk en un porcentaje mayor de l\u00edneas celulares de cnmp que de cmp, y solo encontramos activaci\u00f3n de jnk en un porcentaje bajo de l\u00edneas celulares de cmp. Las c\u00e9lulas que presentan altos niveles de mkp-1\/cl100 tambi\u00e9n tienen activaci\u00f3n de erk. Al tratar estas c\u00e9lulas con un inhibidor espec\u00edfico de la v\u00eda de activaci\u00f3n de erk (u0126), observamos que los niveles de mrna y de prote\u00edna de mkp-1\/cl100 disminuyen, lo que sugiere que erk regula la expresi\u00f3n de esta fosfatasa a nivel transcripcional. los resultados en el modelo animal indican la existencia de una alta expresi\u00f3n de la prote\u00edna de mkp-1 en lesiones preneopl\u00e1sicas (hiperplasias alveolares, bronquiales y lesiones adenomatosas) y niveles bajos o indetectables de estas fosfatasa en el tejido normal y tumoral.  en las muestras cl\u00ednicas, los niveles de expresi\u00f3n de mkp-1\/cl100 son bajos o indetectables en el tejido epitelial normal y en los cmp y elevados en los cnmp. En segundo lugar, en el tejido epitelial normal y en cmp no encontramos activaci\u00f3n de erl y s\u00ed en cnmp pero no en tejido normal y en cmp. Finalmente, observamos que la activaci\u00f3n de erk1\/2 correlaciona postivamente con un estadio avanzado y con tumores de mayor tama\u00f1o y con met\u00e1stasis ga<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio in vitro e in vivo de elementos de la v\u00edade mapk (erk, jnk y mkp-1\/cl100) en la carcinog\u00e9nesis pulmonar<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio in vitro e in vivo de elementos de la v\u00edade mapk (erk, jnk y mkp-1\/cl100) en la carcinog\u00e9nesis pulmonar <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvestre Vicent Cambra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Montuenga Badia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco javier Pardo mind\u00e1n <\/li>\n<li> Madrid cuevas Juan  Francisco (vocal)<\/li>\n<li> Peinado herreros m. \u00e1ngeles (vocal)<\/li>\n<li>enrique Perez paya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvestre Vicent Cambra En este estudio evaluamos el papel de mkp-1\/cl100 y de las mapk, erk y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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