{"id":20171,"date":"2018-03-09T09:09:24","date_gmt":"2018-03-09T09:09:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-regulacion-transcripcional-mediados-por-los-virus-de-la-hepatitis-b-y-c-humanos\/"},"modified":"2018-03-09T09:09:24","modified_gmt":"2018-03-09T09:09:24","slug":"mecanismos-de-regulacion-transcripcional-mediados-por-los-virus-de-la-hepatitis-b-y-c-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-regulacion-transcripcional-mediados-por-los-virus-de-la-hepatitis-b-y-c-humanos\/","title":{"rendered":"Mecanismos de regulaci\u00f3n transcripcional mediados por los virus de la hepatitis b y c humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta G\u00f3mez Gonzalo <\/strong><\/h2>\n<p>Los virus han desarrollado estrategias que les permiten contemplar su ciclo vital, aprovechando la maquinaria celular disponible. En este sentido, los virus codifican para prote\u00ednas implicadas en regular procesos celulares. en el caso del virus de la hepatitis b (hbv) esta funci\u00f3n se ha asociado a la prote\u00edna hbx, mientras que en el virus de la hepatitis c (hcv), la prote\u00edna core es una de las prote\u00ednas virales que presenta esta funci\u00f3n reguladora. En este trabajo de tesis doctoral se presentan datos que indican que la proteina hbx de hbv es capaz de intervenir en el ciclo vital del virus de la inmunodeficiencia humana (hiv-1), favoreciendo los procesos de replicaci\u00f3n\/transcripci\u00f3n viral. Adem\u00e1s de localizar las zonas del ltr de hiv-1 que median dicho efecto, los datos presentados sugieren que hbx podr\u00eda estar ejerciendo una funci\u00f3n coactivadora para activar dicho elemento.  adem\u00e1s, se estudia el mecanismo a trav\u00e9s del cual las prote\u00ednas virales hbx de hbv y core de hcv activan el dominio de transactivaci\u00f3n n-terminal del factor de transcripci\u00f3n nf-at1. En ambos casos se observa interacci\u00f3n con dicho dominio de transactivaci\u00f3n; sin embargo, mientras que hbx interacciona de forma directa con nf-at1, ejerciendo una funci\u00f3n coactivadora para activar dicho factor, la prote\u00edna core se une al dominio de forma indirecta. Se presentan datos que sugieren que el coactivador p300\/cbp podr\u00eda ser un posible candidato para mediar en dicha interacci\u00f3n. Adem\u00e1s, se presenta que la prote\u00edna core de hcv no s\u00f3lo se une a p300\/cbp sino que, adem\u00e1s, aumenta su capacidad transactivadora.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de regulaci\u00f3n transcripcional mediados por los virus de la hepatitis b y c humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de regulaci\u00f3n transcripcional mediados por los virus de la hepatitis b y c humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta G\u00f3mez Gonzalo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Lopez Cabrera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Miguel (secretario) Redondo moya <\/li>\n<li>Manuel Ortiz de landazuri (vocal)<\/li>\n<li>eduardo Mu\u00f1oz blanco (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta G\u00f3mez Gonzalo Los virus han desarrollado estrategias que les permiten contemplar su ciclo vital, aprovechando la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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