{"id":20279,"date":"2018-03-09T09:09:33","date_gmt":"2018-03-09T09:09:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteracion-de-la-homeostasis-ionica-durante-la-lesion-celular-inducida-por-hipoxia-metabolica-papel-de-los-iones-monovalentes\/"},"modified":"2018-03-09T09:09:33","modified_gmt":"2018-03-09T09:09:33","slug":"alteracion-de-la-homeostasis-ionica-durante-la-lesion-celular-inducida-por-hipoxia-metabolica-papel-de-los-iones-monovalentes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteracion-de-la-homeostasis-ionica-durante-la-lesion-celular-inducida-por-hipoxia-metabolica-papel-de-los-iones-monovalentes\/","title":{"rendered":"Alteraci\u00f3n de la homeostasis i\u00f3nica durante la lesi\u00f3n celular inducida por hipoxia metab\u00f3lica. papel de los iones monovalentes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Saloua Zabiti <\/strong><\/h2>\n<p>Recientemente se ha descrito un nuevo tipo de muerte celular denominada oncosis la cual presenta rasgos morfol\u00f3gicos diferentes de la apoptosis, caracteriz\u00e1ndose por tumefacci\u00f3n celular y cariolisis.  la tumefacci\u00f3n celular ha sido relacionada con la alteraci\u00f3n de los mecanismos de regulaci\u00f3n de volumen celular como consecuencia de la falta de atp y la alteraci\u00f3n de la homeostasis i\u00f3nica intracelular.  en este sentido est\u00e1 bien documentado que las alteraciones en la homeostasis i\u00f3nica puede inducir, regular o modificar el mecanismo de muerte celular.  el objetivo de la presente tesis doctoral ha sido evaluar las alteraciones en la composici\u00f3n i\u00f3nica, fundamentalmente en relaci\u00f3n a los iones monovalentes na+, k+ y cl- en la muerte celular por v\u00eda oncotica, y evaluar su posible papel en el desencadenamiento y ejecuci\u00f3n de este tipo particular de muerte celular.  para ello hemos utilizado un modelo experimental de hipoxia metab\u00f3lica en c\u00e9lulas u937, procediendo a la determinaci\u00f3n de las alteraciones i\u00f3nicas durante la lesi\u00f3n celular inducida mediante la aplicaci\u00f3n de microan\u00e1lisis por energ\u00eda dispersiva de rayos-x, m\u00e9todo que permite el an\u00e1lisis de los iones na+, k+ y cl- de forma simult\u00e1nea. El estudio microan\u00e1litico de las c\u00e9lulas u937 sometidas a hipoxia metab\u00f3lica revelo una alteraci\u00f3n de la homeostasis de los iones na+, k+ y cl- en dos fases que se correlacionan de forma directa con las alteraciones morfol\u00f3gicas, ultraestructurales y volum\u00e9tricas caracter\u00edsticas de la muerte celular por oncosis.  la fase inicial se caracteriza por un ligero incremento del volumen celular, aparici\u00f3n de escasas alteraciones ultraestructurales, asociadas a un incremento y descenso de las concentraci\u00f3n de na+, cl- y k+, respectivamente.  estas alteraciones i\u00f3nicas acontecen en c\u00e9lulas que mantienen la integridad de la membrana plasm\u00e1tica y se relacionan con un descenso regulado del volumen (rvd).  la fase tard\u00eda<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraci\u00f3n de la homeostasis i\u00f3nica durante la lesi\u00f3n celular inducida por hipoxia metab\u00f3lica. papel de los iones monovalentes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraci\u00f3n de la homeostasis i\u00f3nica durante la lesi\u00f3n celular inducida por hipoxia metab\u00f3lica. papel de los iones monovalentes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Saloua Zabiti <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/11\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Fern\u00e1ndez Segura<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio M\u00e9rida  velasco <\/li>\n<li>Jos\u00e9 Pe\u00f1a amaro (vocal)<\/li>\n<li> Rodr\u00edguez colunga m. josefa (vocal)<\/li>\n<li> Jimena medina ignacio M\u00aa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Saloua Zabiti Recientemente se ha descrito un nuevo tipo de muerte celular denominada oncosis la cual presenta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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