{"id":20296,"date":"2002-02-12T00:00:00","date_gmt":"2002-02-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/metabolismo-mitocondrial-y-secrecion-de-insulina-en-islotes-pancreaticos-endocrinos\/"},"modified":"2002-02-12T00:00:00","modified_gmt":"2002-02-12T00:00:00","slug":"metabolismo-mitocondrial-y-secrecion-de-insulina-en-islotes-pancreaticos-endocrinos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/metabolismo-mitocondrial-y-secrecion-de-insulina-en-islotes-pancreaticos-endocrinos\/","title":{"rendered":"Metabolismo mitocondrial y secreci\u00f3n de insulina en islotes pancre\u00e1ticos endocrinos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mukala Nsengu Tshibangu Andre <\/strong><\/h2>\n<p>El objetivo general de este trabajo de tesis doctoral fue investigar hasta qu\u00e9 punto la capacidad secretora de insulina por parte del estimulante fisiol\u00f3gico m\u00e1s importante, glucosa, podr\u00eda remedarse cualitativa y cuantitativamente con sustratos de metabolizaci\u00f3n exclusivamente mitocondrial, sorteando la obligatoriedad de la glicolisis que se encuentra afectada en algunos casos de diabetes (mody de tipo ii). La impermeabilidad de algunos intermediarios dicarbox\u00edlicos del ciclo de krebs en la membrana plasm\u00e1tica, como el \u00e1cido succ\u00ednico \u00f3 sad).  el sad estimul\u00f3 de forma dosis-dependiente una secreci\u00f3n bif\u00e1sica mantenida de secreci\u00f3n de insulina en islotes perifundidos de rata. Esta respuesta secretora, as\u00ed como la de la glucosa, fue disminuida en un porcentaje similar al de la decarboxilaci\u00f3n de (2- 14c)piruvato por el dimetil\u00e9ster derivado del \u00e1cido mal\u00f3nico (mad), un inhibidor competitivo del a succ\u00ednico deshidrogenasa mitocondrial.  sin embargo, el inhibidor no modific\u00f3 la velocidad de glicolisis medida como la producci\u00f3n de 3h2o a partir de d-(5-3h)glucosa 20 mm. La combinaci\u00f3n de dos sustratos \u00abmitocondriales\u00bb, como sad y piruvato, permiti\u00f3 alcanzar hasta un 70% de la respuesta secretora m\u00e1xima obtenida por un est\u00edmulo \u00f3ptimo de glucosa. El sad elev\u00f3 el calcio citos\u00f3lico e indujo oscilaciones r\u00e1pidas del mismo de forma similar a la glucosa en islotes aislados de rat\u00f3n.  mientras que el mad inhibi\u00f3 tanto la elevaci\u00f3n del calcio citos\u00f3lico como sus oscilaciones en respuesta a sad, s\u00f3lo sumprimi\u00f3 las oscilaciones pero mantuvo los niveles medios de calcio citos\u00f3lico en presencia de glucosa. la glicolisis parece ser capaz de mantener por si sola unos valores elevados de calcio citos\u00f3lico. La l-glutamina, otro sustrato \u00abmitocondrial\u00bb, se metaboliza bien en las c\u00e9lulas de los islotes (producci\u00f3n de 14co2 a partir de l-alfa-amino\u00e1cido marcado) y elevada las concentraciones intracelulares de l-asp<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Metabolismo mitocondrial y secreci\u00f3n de insulina en islotes pancre\u00e1ticos endocrinos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Metabolismo mitocondrial y secreci\u00f3n de insulina en islotes pancre\u00e1ticos endocrinos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mukala Nsengu Tshibangu Andre <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Tamarit Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: consuelo Calle Garc\u00eda <\/li>\n<li>isabel Valverde alonso (vocal)<\/li>\n<li>Rafael Mart\u00edn del r\u00edo (vocal)<\/li>\n<li> Villanueva pe\u00f1acarillo Mar\u00eda  Luisa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mukala Nsengu Tshibangu Andre El objetivo general de este trabajo de tesis doctoral fue investigar hasta qu\u00e9 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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