{"id":20459,"date":"2002-11-12T00:00:00","date_gmt":"2002-11-12T00:00:00","guid":{"rendered":""},"modified":"2002-11-12T00:00:00","modified_gmt":"2002-11-12T00:00:00","slug":"estudio-inmunocitoqua%c2%admico-de-la-expresion-de-la-protea%c2%adna-del-gen-supresor-tumoral-p53-y-del-infiltrado-inflamatorio-en-las-neoplasias-mamarias-caninas-caractera%c2%adsticas-cla%c2%adnicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunocitoqua%c2%admico-de-la-expresion-de-la-protea%c2%adna-del-gen-supresor-tumoral-p53-y-del-infiltrado-inflamatorio-en-las-neoplasias-mamarias-caninas-caractera%c2%adsticas-cla%c2%adnicas\/","title":{"rendered":"Estudio inmunocitoqu\u00edmico de la expresi\u00f3n de la prote\u00edna del gen supresor tumoral p53 y del infiltrado inflamatorio en las neoplasias mamarias caninas. caracter\u00edsticas cl\u00ednicas e histopatol\u00f3gicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Castillo Mag\u00e1n Noem\u00ed Del <\/strong><\/h2>\n<p>Esta tesis doctoral estudia dos aspectos de los tumores mamarios caninos (tmc), la expresi\u00f3n inmunohistoqu\u00edmica de la prote\u00edna que codifica el gen supresor tumoral p53 y, por otro lado, la caracterizaci\u00f3n del infiltrado inflamatorio asociado a estas neoplasias, analizando en ambos casos su relaci\u00f3n con las caracter\u00edsticas histopatol\u00f3gicas y cl\u00ednicas. Se han estudiado un total de 112 lesiones de la gl\u00e1ndula mamaria y 3 mamas normales en 49 perras.  en la primera visita se anotaron las caracter\u00edsticas  cl\u00ednicas del tumor e historia reproductora de la perra y, una vez extirpadas las neoplasias, se realiz\u00f3 un seguimiento cl\u00ednico durante 18 meses. Las muestras se incluyeron en parafina y se diagnosticaron en funci\u00f3n de la clasificaci\u00f3n de la oms para las neoplasias mamarias caninas y se asign\u00f3 un grado hist\u00f3logico de malignidad (ghm) de ia iii a las neoplasias malignas.  parte de las muestras se congelaron con nitr\u00f3geno l\u00edquido, se conservaron a -80\u00c2\u00bac y se cortaron con el criostato.  la inmunoexpresi\u00f3n de la prote\u00edna p53 se estudi\u00f3 en 89 tmc (12 displasias, 36 tumores benignos y 41 malignos) utilizando los anticuerpos monoclonales pab 240 (n=22 cortes en parafina, n=21 cortes en criostato), do7 (n=69 cortes  en parafina, n=24 en cortes criostato) y pab 1801 (n=68 cortes en parafina) y el anticuerpo policonal cm1 (n=61 cortes en parafina, n=28 cortes en criostato).  en el estudio del infiltrado leucocitario turmoal (ilt) se incluyeron cortes en criostato de 79 tumores (10 displasias, 26 tumores benignos y 43 malignos) y 3 mamas normales empleando varios anticuerpos monoclonales espec\u00edficos frente a las mol\u00e9culas cd caninas.  en un principio el ilt se empelaron 19 anticuerpos anti cd (cd45, cd45ra, cd49, cd18, cd11a, cd11b, cd11c, alfad, cmh tipo ii, cd1a, cd1c, cd3, cd4, cd8alfa, cd8beta, rctalfabeta, rctgamma*, thy-1 y cd21) peso se seleccionaron 9 de acuerdo a los resultados obtenidos (cd45, cd45ra, cd11b, alfad,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio inmunocitoqu\u00edmico de la expresi\u00f3n de la prote\u00edna del gen supresor tumoral p53 y del infiltrado inflamatorio en las neoplasias mamarias caninas. caracter\u00edsticas cl\u00ednicas e histopatol\u00f3gicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunocitoqu\u00edmico de la expresi\u00f3n de la prote\u00edna del gen supresor tumoral p53 y del infiltrado inflamatorio en las neoplasias mamarias caninas. caracter\u00edsticas cl\u00ednicas e histopatol\u00f3gicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Castillo Mag\u00e1n Noem\u00ed Del <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Rodr\u00edguez <\/li>\n<li>Manuel Morales (vocal)<\/li>\n<li>Alberto Montoya (vocal)<\/li>\n<li>valentin Perez perez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Castillo Mag\u00e1n Noem\u00ed Del Esta tesis doctoral estudia dos aspectos de los tumores mamarios caninos (tmc), la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[62256,62254,62253,62255,41397,39448],"class_list":["post-20459","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-alberto-montoya","tag-antonio-rodriguez","tag-castillo-magan-noemi-del","tag-manuel-morales","tag-manuel-rodriguez","tag-valentin-perez-perez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=20459"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20459\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=20459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=20459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=20459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}