{"id":20462,"date":"2002-11-12T00:00:00","date_gmt":"2002-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-caracterizacion-de-hidrogeles-polimericos-con-aplicacion-en-la-liberacion-controlada-de-farmacos\/"},"modified":"2002-11-12T00:00:00","modified_gmt":"2002-11-12T00:00:00","slug":"desarrollo-y-caracterizacion-de-hidrogeles-polimericos-con-aplicacion-en-la-liberacion-controlada-de-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-caracterizacion-de-hidrogeles-polimericos-con-aplicacion-en-la-liberacion-controlada-de-farmacos\/","title":{"rendered":"Desarrollo y caracterizaci\u00f3n de hidrogeles polim\u00e9ricos con aplicaci\u00f3n en la liberaci\u00f3n controlada de f\u00e1rmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva D\u00edez Pe\u00f1a <\/strong><\/h2>\n<p>Se han preparado hidrogeles basados en n-isopropilacrilamida (n-ipaam) y \u00e1cido metacr\u00edlico (maa) que presentan un comportamiento de hinchamiento capaz de responder a est\u00edmulos del medio.  mediante el estudio de las propiedades t\u00e9rmicas, y experimentos de rmn en estado s\u00f3lido se ha determinado la existencia de complejos interpolim\u00e9ricos por puentes de hidr\u00f3geno entre ambos mon\u00f3meros, que tienen lugar cuando las muestras son tratadas a ph \u00e1cido y est\u00e1n estabilizados por interacciones hidrof\u00f3bicas. Esto da lugar a una marcada dependencia con el ph del medio en el que se lleva a cabo el hinchamiento; a phs ligeramente b\u00e1sicos el equilibrio de hinchamiento depende del grado de entrecruzamiento qu\u00edmico, mientras que a phs \u00e1cidos las muestras presentan valores de equilibrio muy bajos a causa del entrecruzamiento f\u00edsico adicional debido a la formaci\u00f3n de  los complejos.  la sensibilidad t\u00e9rmica no es tan significativa, aunque los copol\u00edmeros ricos en n-ipaam, s\u00ed presentan sensibilidad tanto al ph como a la temperatura.  el hinchamiento din\u00e1mico presenta dos efectos an\u00f3malos caracter\u00edsticos:  1,- a ph b\u00e1sico, una cin\u00e9tica de absorci\u00f3n muy lenta con curvas de tendencia sigmoidal, que se ha interpretado como un proceso autocatal\u00edtico debido a la lenta rotura de los complejos.  2,- a ph \u00e1cido, un proceso de hinchamiento-deshinchamiento (efecto \u00abovershooting\u00bb), debido a una reorganizaci\u00f3n de la estructura promovida por la entrada del disolvente, que da lugar a la formaci\u00f3n de los complejos. Ambos efectos pueden ser puestos de manifiesto de forma controlada, regulando la cantidad de puetnes de hidr\u00f3geno en los geles mediante tratamientos previos a phs \u00e1cido o b\u00e1sico. Se ha explorado el emplemo de las muestras en sistemas de administraci\u00f3n de f\u00e1rmacos por v\u00eda oral de activaci\u00f3n controlada por el ph. Los copol\u00edmeros de mayor contenido en n-ipaam son los m\u00e1s efectivos permitiendo obtener curvas de cesi\u00f3n muy di<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y caracterizaci\u00f3n de hidrogeles polim\u00e9ricos con aplicaci\u00f3n en la liberaci\u00f3n controlada de f\u00e1rmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y caracterizaci\u00f3n de hidrogeles polim\u00e9ricos con aplicaci\u00f3n en la liberaci\u00f3n controlada de f\u00e1rmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva D\u00edez Pe\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Paloma Frutos Cabanillas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lastres garcia <\/li>\n<li>alessandro Ganidini (vocal)<\/li>\n<li> Barrales rienda Jos\u00e9 Manuel (vocal)<\/li>\n<li>Juan  Jos\u00e9 Freire gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva D\u00edez Pe\u00f1a Se han preparado hidrogeles basados en n-isopropilacrilamida (n-ipaam) y \u00e1cido metacr\u00edlico (maa) que presentan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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