{"id":20475,"date":"2002-11-12T00:00:00","date_gmt":"2002-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/coste-biologico-y-regulacion-de-la-resistencia-multiple-a-los-antibioticos\/"},"modified":"2002-11-12T00:00:00","modified_gmt":"2002-11-12T00:00:00","slug":"coste-biologico-y-regulacion-de-la-resistencia-multiple-a-los-antibioticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/coste-biologico-y-regulacion-de-la-resistencia-multiple-a-los-antibioticos\/","title":{"rendered":"Coste biol\u00f3gico y regulaci\u00f3n de la resistencia m\u00faltiple a los antibi\u00f3ticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1nchez D\u00edaz Patricia C. <\/strong><\/h2>\n<p>El informe de la oms del a\u00f1o 2000 puso de manifiesto que las enfermedades infectocontagiosas constituyen el mayor problema sanitario de nuestro tiempo. en este contexto, las infecciones causadas por microorganismos resistentes a los antibi\u00f3ticos, entre los que destacan los pat\u00f3genos oportunistas, adquieren especial importancia.  se denominan pat\u00f3genos oportunistas a una serie de microorganismos que producen enfermedad \u00fanicamente en individuos inmunodeprimidos o con patolog\u00edas base que generalmente se encuentran sometidos a terapias antimicrobianas severas. Entre los pat\u00f3genos oportunistas m\u00e1s importantes en el desarrollo de infecciones hospitalarias se encuentra pseudomonas aeruginosa. Recientemente, stenotrophomonas maltophilia, otro pat\u00f3geno oportunista, est\u00e1 adquiriendo cierta relevancia.  ambos microorganismos se caracterizan por poseer una elevada resistencia intr\u00ednseca a los antibi\u00f3ticos y por ser capaces de adquirir niveles de resistencia a\u00fan mayores tras la terapia antiinfecciosa. Entre los mecanismos de resistencia a los antibi\u00f3ticos identificados en ambas especies bacterianas se encuentra la expresi\u00f3n de sistemas de expulsi\u00f3n m\u00faltiple de drogas (mdr).  se denominan sistemas mdr a una serie de transportadores que de forma relativamente inespec\u00edfica expulsan una serie de compuestos no relacionados entre s\u00ed estructuralmente.  algunas de las caracter\u00edsticas de este tipo de sistemas son:  ubicuidad: pues se han encontrado en todas las estirpes de todas las especies analizadas.  multiplicidad: pues en un mismo organismo se han encontrado hasta 20 genes que codifican distintos sistemas mdr.  funci\u00f3n, generalmente, desconocida: se ha especulado que est\u00e9n implicados en detoxificaci\u00f3n, o incluso en se\u00f1alizaci\u00f3n intercelular.  en p.Aeruginosa se ha caracterizado 5 sistemas mdr: mexab-oprm, mexcd-oprj, mexef, oprn, mexxy-oprm y mexjk-oprm; y en s.Maltophilia dos: smedef y smeabc. La relevancia cl\u00ednica de a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Coste biol\u00f3gico y regulaci\u00f3n de la resistencia m\u00faltiple a los antibi\u00f3ticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Coste biol\u00f3gico y regulaci\u00f3n de la resistencia m\u00faltiple a los antibi\u00f3ticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1nchez D\u00edaz Patricia C. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Lu\u00eds Mart\u00ednez Men\u00e9ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victor De lorenzo prieto <\/li>\n<li>Juan  alfonso Ayala serrano (vocal)<\/li>\n<li>Fernando Baquero mochales (vocal)<\/li>\n<li>jordi Vila estape (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1nchez D\u00edaz Patricia C. El informe de la oms del a\u00f1o 2000 puso de manifiesto que las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[2719,62290,29795,30037,62289,4203],"class_list":["post-20475","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-fernando-baquero-mochales","tag-jordi-vila-estape","tag-jose-luis-Martinez-menendez","tag-juan-alfonso-ayala-serrano","tag-sanchez-diaz-patricia-c","tag-victor-de-lorenzo-prieto"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20475","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=20475"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20475\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=20475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=20475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=20475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}