{"id":20556,"date":"2018-03-09T09:09:56","date_gmt":"2018-03-09T09:09:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-fenota%c2%adpico-y-funcional-de-las-poblaciones-celulares-t-y-nkt-asociadas-al-envejecimiento\/"},"modified":"2018-03-09T09:09:56","modified_gmt":"2018-03-09T09:09:56","slug":"estudio-fenota%c2%adpico-y-funcional-de-las-poblaciones-celulares-t-y-nkt-asociadas-al-envejecimiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/estudio-fenota%c2%adpico-y-funcional-de-las-poblaciones-celulares-t-y-nkt-asociadas-al-envejecimiento\/","title":{"rendered":"Estudio fenot\u00edpico y funcional de las poblaciones celulares t y nkt asociadas al envejecimiento"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Olga De La Rosa Morales <\/strong><\/h2>\n<p>1,- en individuos ancianos sanos se ha observado un incremento en la poblaci\u00f3n de linfocitos t cd28- en comparaci\u00f3n con la poblaci\u00f3n de c\u00e9lulas cd3+cd28-. esta poblaci\u00f3n de c\u00e9lulas t cd3+cd28- se caracteriza por poseer tel\u00f3mero corto, ser mayoritariamente cd8+, poseer mayor expresi\u00f3n de receptores asociados a c\u00e9lulas nk, contener perforina intracelular y poseer mayor expresi\u00f3n de cd45ro que de cd45ra.  2,- la poblaci\u00f3n cd3+cd28- de individuos ancianos en comparaci\u00f3n con la poblaci\u00f3n cd3+cd28- de individuos j\u00f3venes se caracteriza por poseer un incremento en la expresi\u00f3n de los marcadores asociados a c\u00e9lulas nk cd56, cd16, ilt2 y kir2dl1, y disminuci\u00f3n en la expresi\u00f3n de cd161, poseer menor porcentaje de perforina intracelular y poseer mayor canal medio de fluorescencia de cd45ro.  3,- los linfoctios t cd8+ de individuos ancianos poseen incrementada la producci\u00f3n de ifn-gamma tanto en respuesta a pma e inomicina como en respuesta al p\u00e9ptido flump58-66 comparado con linfocitos t cd8+ de controles j\u00f3venes.  4,- la poblaci\u00f3n de linfocitos nkt definida por expresar el receptor t valfa24+vbeta11+ est\u00e1 disminuida en individuos ancianos en comparaci\u00f3n con controles j\u00f3venes.  5,- esta poblaci\u00f3n de c\u00e9lulas nkt en individuos j\u00f3venes est\u00e1 caracterizada por la expresi\u00f3n mayoritaria (&gt; 80%) de cd28, cd45ro y cd161, niveles bajos de expresi\u00f3n (15-30%) de cd94\/nkg2a, cd56 y de cd244 y no expresi\u00f3n (&lt;5%) de kir2dl1, kir2dl2, ilt-2 y cd25. No se encuentra diferencias asociadas al envejecimiento en la expresi\u00f3n de cd28, cd45ro y cd161, mientras que la expresi\u00f3n de cd56 est\u00e1 incrementada.  6,- las c\u00e9lulas nkt que producen ifn-gamma y e il-4 pertenecen preferentemente a la subpoblaci\u00f3n nkt cd4+ tanto en individuos j\u00f3venes como en ancianos. las c\u00e9lulas nkt de individuos ancianos presentan un incremento en la producci\u00f3n de ifn-gamma e il-4 en respuesta a pma e ionomicina en comparaci\u00f3n con las c\u00e9lulas nkt de c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio fenot\u00edpico y funcional de las poblaciones celulares t y nkt asociadas al envejecimiento<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio fenot\u00edpico y funcional de las poblaciones celulares t y nkt asociadas al envejecimiento <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Olga De La Rosa Morales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Solana Lara<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez guijo <\/li>\n<li>raquel Tarrazona lafarga (vocal)<\/li>\n<li>ignacio Molina pineda de las infantas (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Olga De La Rosa Morales 1,- en individuos ancianos sanos se ha observado un incremento en la 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