{"id":20564,"date":"2018-03-09T09:09:57","date_gmt":"2018-03-09T09:09:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-melatonina-y-los-derivados-sinteticos-kinureninicos-en-el-modelo-experimental-de-epilepsia-inducida-por-ptz\/"},"modified":"2018-03-09T09:09:57","modified_gmt":"2018-03-09T09:09:57","slug":"efecto-de-la-melatonina-y-los-derivados-sinteticos-kinureninicos-en-el-modelo-experimental-de-epilepsia-inducida-por-ptz","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-melatonina-y-los-derivados-sinteticos-kinureninicos-en-el-modelo-experimental-de-epilepsia-inducida-por-ptz\/","title":{"rendered":"Efecto de la melatonina y los derivados sint\u00e9ticos kinureninicos en el modelo experimental de epilepsia inducida por ptz"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leila Bikjdaouene <\/strong><\/h2>\n<p>Recientemente se ha demostrado que algunas kinureninas sint\u00e9ticas, estructuralmente similares a los metabolitos de la melatonina, son antagonistas de receptor nmda inhibiendo la nnos.  en este trabajo se ha demostrado el efecto anticonvulsivante de la melatonina y de ciertas kinureninas sint\u00e9ticas, determin\u00e1ndose los niveles de amino\u00e1cidos y \u00f3xido n\u00edtrico en el modelo de epilepsia inducida por el pentilentetrazol.  las ratas se trataron con melatonina y dichas kinureninas a dosis de 10 a 160 mg\/kg s.C., 30 min antes de la administraci\u00f3n de ptz (100 mg\/kg s.C.). se evaluaron la latencia, duraci\u00f3n e intensidad de la primera convulsi\u00f3n y la supervivencia a las tres horas.  la dosis administrada de ptz caus\u00f3 una alta mortalidad (80%), que fue contrarrestada por la melatonina y las kinureninas a dosis altas, aumentando significativamente la latencia de la primera crisis y disminuyendo la intensidad y la duraci\u00f3n de forma dosis-dependiente.  tres horas despu\u00e9s de ptz se sacrificaron los animales que sobrevivieron y se determinaron los niveles de amino\u00e1cidos y del \u00f3xido n\u00edtrico.  la administraci\u00f3n de ptz disminuye el nivel de aspartato y aumenta lo del glutamato, glutamina, serina y taurina en las distintas \u00e1reas estudiadas.  la melatonina contrarresta el efecto de ptz de la dosis 10 a 40 mg\/kg, reduciendo el glutamato, aspartato y serina a partir de la dosis 40 mg\/kg y aumenta el gaba, taurina y glicina en la mayor\u00eda de las \u00e1reas estudiadas. tambi\u00e9n altas dosis de estos compuestos kinuren\u00ednicos contrarrestan el efecto de ptz reduciendo los amino\u00e1cidos excitadores a partir de la dosis 40 mg\/kg. Sin embargo el efecto m\u00e1s significativo tanto de la melatonina como de la kinureninas se observa a nivel del \u00f3xido n\u00edtrico alterado despu\u00e9s de ptz. La melatonina lo disminuye a partir de la dosis 40 mg\/kg y las kinureninas a todas las dosis en la mayor\u00eda de las \u00e1reas estudiadas. Estos resultados indican que la melatonina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la melatonina y los derivados sint\u00e9ticos kinureninicos en el modelo experimental de epilepsia inducida por ptz<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la melatonina y los derivados sint\u00e9ticos kinureninicos en el modelo experimental de epilepsia inducida por ptz <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leila Bikjdaouene <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Dario Acu\u00f1a Castroviejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Espinosa \u00fabeda <\/li>\n<li>josefa Rodr\u00edguez colunga (vocal)<\/li>\n<li>Antonio Mu\u00f1oz hoyos (vocal)<\/li>\n<li>Jos\u00e9 Garc\u00eda Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leila Bikjdaouene Recientemente se ha demostrado que algunas kinureninas sint\u00e9ticas, estructuralmente similares a los metabolitos de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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