{"id":20638,"date":"2018-03-09T09:10:03","date_gmt":"2018-03-09T09:10:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cambios-bioqua%c2%admicos-y-ultraestructurales-en-un-modelo-in-vivo-de-estres-oxidativo-retiniano-en-el-raton-apo-e-deficiente-tratado-con-diferentes-sustancias-antioxidantes\/"},"modified":"2018-03-09T09:10:03","modified_gmt":"2018-03-09T09:10:03","slug":"cambios-bioqua%c2%admicos-y-ultraestructurales-en-un-modelo-in-vivo-de-estres-oxidativo-retiniano-en-el-raton-apo-e-deficiente-tratado-con-diferentes-sustancias-antioxidantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/cambios-bioqua%c2%admicos-y-ultraestructurales-en-un-modelo-in-vivo-de-estres-oxidativo-retiniano-en-el-raton-apo-e-deficiente-tratado-con-diferentes-sustancias-antioxidantes\/","title":{"rendered":"Cambios bioqu\u00edmicos y ultraestructurales en un modelo in vivo de estr\u00e9s oxidativo retiniano en el rat\u00f3n apo-e deficiente tratado con diferentes sustancias antioxidantes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Manuel S\u00e1daba Echarri <\/strong><\/h2>\n<p>Una de las principales l\u00edneas de investigaci\u00f3n es la relaci\u00f3n entre la hipercolesterolemia, los fen\u00f3menos de oxidaci\u00f3n y su influencia en el desarrollo de algunas enfermedades, sobretodo degenerativas. Los objetivos de este trabajo han sido estudiar el estr\u00e9s oxidativo y el efecto de diferentes sustancias antioxidantes en la retina y en el plasma en el rat\u00f3n apo-e deficiente y estudiar los cambios morfol\u00f3gicos y ultraestructurales en la retina. Para ello se emplearon ratones c57bl\/6 machos, 10 normales y 50 deficientes en la apolipoprote\u00edna-e (apo-e -\/-). La duraci\u00f3n del experimento fue de tres meses. Los antioxidantes empleados fueron la cromocarbo dietilamina, el cloruro de cian\u00f3sidos, un preparado multivitam\u00ednico y mineral y las vitaminas c y e. Se realizaron determinaciones de peroxidaci\u00f3n lip\u00eddica (tbars) en retina y plasma y de \u00f3xido n\u00edtrico en retina. El estudio histol\u00f3gico se realiz\u00f3 mediante microscopio \u00f3ptico y electr\u00f3nico. Se observ\u00f3 que los ratones apo-e -\/- presentaban un elevado estr\u00e9s oxidativo en retina y plasma y una mayor producci\u00f3n de no en retina, tambi\u00e9n mostraban alteraciones ultraestructurales en forma de dep\u00f3sitos y vacuolas en la membrana de bruch. no se encontraron cambios en el microscopio \u00f3ptico. Las vitaminas c y e lograron disminuir la peroxidaci\u00f3n lip\u00eddica en el plasma y en la retina y los niveles de \u00f3xido n\u00edtrico en la retina de los ratones apo-e -\/-. El grupo tratado con el compuesto multivitam\u00ednico mostr\u00f3 una disminuci\u00f3n de tbars en retina y tanto el compuesto multivitam\u00ednico como las vitaminas c y e lograron normalizar las alteraciones ultraestructurales descritas en la retina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cambios bioqu\u00edmicos y ultraestructurales en un modelo in vivo de estr\u00e9s oxidativo retiniano en el rat\u00f3n apo-e deficiente tratado con diferentes sustancias antioxidantes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cambios bioqu\u00edmicos y ultraestructurales en un modelo in vivo de estr\u00e9s oxidativo retiniano en el rat\u00f3n apo-e deficiente tratado con diferentes sustancias antioxidantes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Manuel S\u00e1daba Echarri <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Garc\u00eda Layana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Ram\u00edrez sebasti\u00e1n <\/li>\n<li>Jos\u00e9 Antonio Paramo fernandez (vocal)<\/li>\n<li>Jos\u00e9 Garc\u00eda arum\u00ed (vocal)<\/li>\n<li> Saornil alvarez m. antonia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Manuel S\u00e1daba Echarri Una de las principales l\u00edneas de investigaci\u00f3n es la relaci\u00f3n entre la hipercolesterolemia, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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