{"id":20708,"date":"2018-03-09T09:10:09","date_gmt":"2018-03-09T09:10:09","guid":{"rendered":""},"modified":"2018-03-09T09:10:09","modified_gmt":"2018-03-09T09:10:09","slug":"bajas-dosis-de-paclitaxel-semanal-como-tratamiento-quimioterapico-en-pacientes-pretratados-o-ancianos-con-diagnostico-de-carcinoma-de-pulmon-de-celula-no-pequena-valoracion-electrofisiologica-de-la-n","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bajas-dosis-de-paclitaxel-semanal-como-tratamiento-quimioterapico-en-pacientes-pretratados-o-ancianos-con-diagnostico-de-carcinoma-de-pulmon-de-celula-no-pequena-valoracion-electrofisiologica-de-la-n\/","title":{"rendered":"Bajas dosis de paclitaxel semanal como tratamiento quimioter\u00e1pico en pacientes pretratados o ancianos con diagn\u00f3stico de carcinoma de pulm\u00f3n de c\u00e9lula no peque\u00f1a. valoraci\u00f3n electrofisiol\u00f3gica de la neurotoxicidad y estudio farmacocin\u00e9tico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Oscar Juan Vidal Jose <\/strong><\/h2>\n<p>El paclitaxel semanal a dosis de 80 mg\/m2 en infusi\u00f3n de 1 hora, muestra alta actividad cl\u00ednica en t\u00e9rminos de respuesta global (40%) en pacientes con cpcnp no candidatos a quimioterapia con combinaciones de platino (por haber recibido tratamiento previo o por comorbilidades o edad avanzada). la mediana de supervivencia (8,4 meses) y el tiempo a la progresi\u00f3n (5,4 meses) son similares a los obtenidos con combinaciones de quimioterapia.  la toxicidad hematol\u00f3gica grave est\u00e1 ausente. La toxicidad no hematol\u00f3gica fue leve (grado 1-2 seg\u00fan escala nci-ctc): astenia (56%), alopecia (64%), anorexia (53%), neuropat\u00eda sensitiva (50%) y motora (47%).  la gradaci\u00f3n de la severidad de la neuropat\u00eda perif\u00e9rica muestra gran variabilidad entre observadores (65%). Es necesario desarrollar un m\u00e9todo que recoja de forma objetiva la severidad de la neurotoxicidad.  la exploraci\u00f3n neurofisiol\u00f3gica de miembros superiores e inferiores diang\u00f3stica la presencia de neuropat\u00eda sensitiva o sensitivo-motora en el 94% de nuestra poblaci\u00f3n. S\u00f3lo un 30% presentaban s\u00edntomas cl\u00ednicos, por lo que se diagn\u00f3stica un alto porcentaje de neuropat\u00eda subcl\u00ednica. No existe disminuci\u00f3n significativa (estad\u00edstica) de los par\u00e1metros medidos tras 8 semanas de tratamiento con paclitaxel.  estudio farmacocin\u00e9tico: la administraci\u00f3n previa al paclitael de amifostina produce alteraci\u00f3n de casi la totalidad de variables estudiadas, a excepci\u00f3n del auc y cl. La cmax es estad\u00edsticamente superior en aquellos pacientes que s\u00f3lo recibieron paclitaxel. El t 0,1 mcm y t 0,05 mcm para el paclitaexl fue m\u00e1s prolongado de forma estad\u00edsticamente significativa en pacientes que recibieron amifostina m\u00e1s paclitaexl. No se observ\u00f3 variabilidad de los par\u00e1metros farmacocin\u00e9ticos intra-paciente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bajas dosis de paclitaxel semanal como tratamiento quimioter\u00e1pico en pacientes pretratados o ancianos con diagn\u00f3stico de carcinoma de pulm\u00f3n de c\u00e9lula no peque\u00f1a. valoraci\u00f3n electrofisiol\u00f3gica de la neurotoxicidad y estudio farmacocin\u00e9tico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bajas dosis de paclitaxel semanal como tratamiento quimioter\u00e1pico en pacientes pretratados o ancianos con diagn\u00f3stico de carcinoma de pulm\u00f3n de c\u00e9lula no peque\u00f1a. valoraci\u00f3n electrofisiol\u00f3gica de la neurotoxicidad y estudio farmacocin\u00e9tico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Oscar Juan Vidal Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Arberola Candel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda conde bru javier <\/li>\n<li>victor Jimenez torres (vocal)<\/li>\n<li>alfredo Carrato mena (vocal)<\/li>\n<li>Antonio Lorenzo pe\u00f1uelas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oscar Juan Vidal Jose El paclitaxel semanal a dosis de 80 mg\/m2 en infusi\u00f3n de 1 hora, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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