{"id":20754,"date":"2018-03-09T09:10:12","date_gmt":"2018-03-09T09:10:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-artritis-reumatoide-identificacion-de-marcadores-geneticos-de-susceptibilidad-pronostico\/"},"modified":"2018-03-09T09:10:12","modified_gmt":"2018-03-09T09:10:12","slug":"bases-moleculares-de-la-artritis-reumatoide-identificacion-de-marcadores-geneticos-de-susceptibilidad-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/bases-moleculares-de-la-artritis-reumatoide-identificacion-de-marcadores-geneticos-de-susceptibilidad-pronostico\/","title":{"rendered":"Bases moleculares de la artritis reumatoide: identificaci\u00f3n de marcadores gen\u00e9ticos de susceptibilidad-pron\u00f3stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pascual Martinez M. Dolores <\/strong><\/h2>\n<p>El objetivo general de la presente tesis ha consistido en profundizar en el conocimiento de las bases gen\u00e9ticas que subyacen a la etiopatog\u00e9nesis de una patolog\u00eda compleja de origen multifactorial como es la artritis reumatoide (ar), mediante la b\u00fasqueda de posibles nuevos marcadores gen\u00e9ticos con valor predictivo de susceptibilidad y\/o pron\u00f3stico de la enfermedad.  los genes hla de la clase ii son los \u00fanicos genes que hasta la fecha se ha asociado con un total consenso con la susceptibilidad a la enfermedad, observaciones cl\u00e1sicamente explicadas mediante la teor\u00eda del ep\u00edtopo compartido.  el modelo alternativo y recientemente propuesto de susceptibilidad gen\u00e9tica a la ar (modelo rap) permtie una mejor distinci\u00f3n entre enfermos y controles que la teor\u00eda del ep\u00edtopo compartido en t\u00e9rminos de susceptibilidad y protecci\u00f3n.  en nuestra poblaci\u00f3n, el haplotipo dq3-dr4 es el que confiere una mayor susceptibilidad a la enfermedad.  se conoce que existen locus de susceptibilidad adicionales a los genes de clase ii en la regi\u00f3n hla.  tras el an\u00e1lisis de bater\u00edas de microsat\u00e9lites (ms) hla, hemos establecido la existencia de clusters extendidos de ms empleando de manera independiente 2 poblaciones europeas de distinto fondo gen\u00e9tico y con diferencias en cuanto a la preValencia y a la severidad de la ar. Esta reproducci\u00f3n de los datos es una garant\u00eda de la validez de los mismos y a su vez que nuestra aproximaci\u00f3n metodol\u00f3gica del empleo de ms polim\u00f3rficos hla es \u00fatil a la hora de definir configuraciones hla. La segregaci\u00f3n de los haplotipo definido como c1 (d6s1014*143-d6s273*139-d6stnfa*99-mib*350-c1-2-5*196), correspondiente al haplotipo drb1*0301-b*0801 result\u00f3 estar asociado a la predisposici\u00f3n a la ar independientemente a los genes de clase ii y confirma la contribuci\u00f3n de un locus segundo locus de susceptibilidad en la regi\u00f3n telom\u00e9rica de la regi\u00f3n hla.  el mencionado haplotipo c1 (que aparece disminuid<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases moleculares de la artritis reumatoide: identificaci\u00f3n de marcadores gen\u00e9ticos de susceptibilidad-pron\u00f3stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases moleculares de la artritis reumatoide: identificaci\u00f3n de marcadores gen\u00e9ticos de susceptibilidad-pron\u00f3stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pascual Martinez M. Dolores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Martin Iba\u00f1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: e.n. Ollier william <\/li>\n<li> G\u00f3mez de la concha Emilio (vocal)<\/li>\n<li>dolores Jaraquemada p\u00e9rez de guzm\u00e1n (vocal)<\/li>\n<li>mario Delgado mora (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pascual Martinez M. Dolores El objetivo general de la presente tesis ha consistido en profundizar en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,155,9,1086,2820,139,877],"tags":[6522,63007,5124,45178,63008,63006],"class_list":["post-20754","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-ciencias-clinicas","category-ciencias-medicas","category-epidemiologia","category-genetica-humana","category-medicina-interna","category-reumatologia","tag-dolores-jaraquemada-perez-de-guzman","tag-e-n-ollier-william","tag-gomez-de-la-concha-emilio","tag-javier-martin-ibanez","tag-mario-delgado-mora","tag-pascual-Martinez-m-dolores"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=20754"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20754\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=20754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=20754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=20754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}