{"id":20772,"date":"2018-03-09T09:10:14","date_gmt":"2018-03-09T09:10:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alfa-amino-aldeha%c2%addos-quirales-como-productos-de-partida-en-la-sa%c2%adntesis-de-hidroxiamino-derivados-enantiomericamente-puros\/"},"modified":"2018-03-09T09:10:14","modified_gmt":"2018-03-09T09:10:14","slug":"alfa-amino-aldeha%c2%addos-quirales-como-productos-de-partida-en-la-sa%c2%adntesis-de-hidroxiamino-derivados-enantiomericamente-puros","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/valladolid\/alfa-amino-aldeha%c2%addos-quirales-como-productos-de-partida-en-la-sa%c2%adntesis-de-hidroxiamino-derivados-enantiomericamente-puros\/","title":{"rendered":"Alfa-amino aldeh\u00eddos quirales como productos de partida en la s\u00edntesis de hidroxiamino derivados enantiom\u00e9ricamente puros"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Elena Pe\u00f1a Noem\u00ed De <\/strong><\/h2>\n<p>Se ha puesto a punto un m\u00e9todo de s\u00edntesis estereodivergente de alfa-amino-beta-hidroxi \u00e1cidos, ep\u00edmeros en c-3, utilizando como productos de partida los alfa-amino aldeh\u00eddos derivados de l-serina: (s)-n,n-dibencil-o-tbdms-serinal y (s)-n,n-dibencil-obo-serinal. la etapa clave de la s\u00edntesis es la alquilaci\u00f3n diastereoselectiva de los citados amino aldeh\u00eddos con reactivos organoc\u00ednicos y magnesianos que conduce respectivamente a los aductos syn y anti con buenos rendimientos qu\u00edmicos y excesos diastereom\u00e9ricos. De este modo hemos realizado la preparaci\u00f3n de los cuatro diasterois\u00f3meros de la beta-hidroxi norvalina, de la (2r-3s)-3-hidroxileucina y de la (2r, 3s)-fenilserina, compuestos de inter\u00e9s farmacol\u00f3gico.  la extensi\u00f3n de nuestros estudios a los n,n-dibencilamino aldeh\u00eddos derivados de los \u00e1cidos l-asp\u00e1rtico y l-glut\u00e1mico, nos ha permitido la s\u00edntesis esteroeselectiva de beta-amino-gamma-hidroxi \u00e1cidos y de gamma-amino-*-hidroxi \u00e1cidos, compuestos tambi\u00e9n de gran inter\u00e9s por su posible utilizaci\u00f3n como inhibidores enzim\u00e1ticos. adem\u00e1s hemos abordado la s\u00edntesis de la treo y eritro aza-muricatacina, hidroxi pirrolidonas aza-an\u00e1logas de la muricatacina que muestran una interesante y similar citotoxicidad, a partir del alfa-deibencilamino aldeh\u00eddo derivado del \u00e1cido l-glut\u00e1mico.  finalmente, hemos estudiado la reacci\u00f3n de n-bencil aziridino aldeh\u00eddos, derivaods de la l-serina y de la l-treonina, con dialquilzinc y haluros de alquilmagnesio, lo que nos ha permitido la preparaci\u00f3n de syn-aziridino alcoholes, compuestos de gran utilidad como catalizadores quirales en procesos enantioselectivos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alfa-amino aldeh\u00eddos quirales como productos de partida en la s\u00edntesis de hidroxiamino derivados enantiom\u00e9ricamente puros<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alfa-amino aldeh\u00eddos quirales como productos de partida en la s\u00edntesis de hidroxiamino derivados enantiom\u00e9ricamente puros <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Elena Pe\u00f1a Noem\u00ed De <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Pedrosa Saez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Garc\u00eda ruano <\/li>\n<li>mercedes Amat tus\u00f3n (vocal)<\/li>\n<li>carmen N\u00e1jera domingo (vocal)<\/li>\n<li> Bad\u00eda urrestarazu Mar\u00eda dolores (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Pe\u00f1a Noem\u00ed De Se ha puesto a punto un m\u00e9todo de s\u00edntesis estereodivergente de alfa-amino-beta-hidroxi \u00e1cidos, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12451],"tags":[41749,19243,63048,5621,13779,12840],"class_list":["post-20772","post","type-post","status-publish","format-standard","hentry","category-valladolid","tag-badia-urrestarazu-maria-dolores","tag-carmen-najera-domingo","tag-elena-pena-noemi-de","tag-jose-luis-garcia-ruano","tag-mercedes-amat-tuson","tag-rafael-pedrosa-saez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=20772"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20772\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=20772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=20772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=20772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}