{"id":20777,"date":"2018-03-09T09:10:16","date_gmt":"2018-03-09T09:10:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-respuesta-inmunologica-por-la-inmunoterapia-con-dermatophagoides-pteronyssinus-relacion-con-la-eficacia-cla%c2%adnica\/"},"modified":"2018-03-09T09:10:16","modified_gmt":"2018-03-09T09:10:16","slug":"modulacion-de-la-respuesta-inmunologica-por-la-inmunoterapia-con-dermatophagoides-pteronyssinus-relacion-con-la-eficacia-cla%c2%adnica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-respuesta-inmunologica-por-la-inmunoterapia-con-dermatophagoides-pteronyssinus-relacion-con-la-eficacia-cla%c2%adnica\/","title":{"rendered":"Modulaci\u00f3n de la respuesta inmunol\u00f3gica por la inmunoterapia con dermatophagoides pteronyssinus. relaci\u00f3n con la eficacia cl\u00ednica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Vict\u00f3ria Cardona Dahl <\/strong><\/h2>\n<p>Antecedentes  las enfermedades al\u00e9rgicas se han asociado a un desequilibrio inmunol\u00f3gico consistente en un predominio de la respuesta th2 sobre la th1. Determinadas mol\u00e9culas expresadas en la superficie de las c\u00e9lulas presentadoras de ant\u00edgeno (cpa) son fundamentales para la activaci\u00f3n de los linfocitos t (lt) y tambi\u00e9n para inducir la derivaci\u00f3n hacia la producic\u00f3n de un determinado tipo de citocinas th1 o th2. Es posible que los pacientes al\u00e9rgicos presenten alteraciones en la expresi\u00f3n de estas mol\u00e9culas y que lainmunoterapia (it) revierta esta alteraci\u00f3n.  objetivo  investigar en individuos sanos y pacientes al\u00e9rgicos la expresi\u00f3n de cd23 y cd86 (b7.2) en linfocitos b (lb) y monocitos (m) y la expresi\u00f3n intracelular de il-4, il-10 y ifn-gama en lt. Estudiar en los pacientes al\u00e9rgicos, los posibles cambios inducidos por la it en estos par\u00e1metros, as\u00ed como el efecto de este tratamiento en la sensibilizaci\u00f3n al alergeno, los s\u00edntomas y el uso de medicaci\u00f3n.  metodos  estudio prospectivo, abierto, aleatorizado con grupo control. Sujetos: 10 individuos sanos y 28 pacientes asm\u00e1ticos, monosensibilizados a dermatophagoides pteronyssinus (d pteronyssinus), 16 tratados con it y 12 sin it.  m\u00e9todos: pruebas cut\u00e1neas y provocaci\u00f3n conjuntival a d pteronyssinus. control de la puntuaci\u00f3n de s\u00edntomas y del uso de medicaci\u00f3n. Determinaci\u00f3n mediante citometr\u00eda de flujo, del porcentaje de lt cd69+ y el porcentaje de lt que expresaban il-4, il-10 y ifn-gama, en cultivos de c\u00e9lulas mononucleadas de sangre perif\u00e9rica, estimulados con pma y ionomicina o estimulados con d pteronyssinus y sometidos a reestimulaci\u00f3n. Estudio de la proliferaci\u00f3n linfocitaria frente a d pteronyssinus. Evaluaci\u00f3n del porcentaje de lb (cd20+) de m (cd14+) que expresaban cd23 o cd86. En los individuos al\u00e9gicos se realiz\u00f3 el control cl\u00ednico y el estudio \u00abin vitro\u00bb al inicio del estudio (t1), a los 6 meses (t2) ya los 12 meses (t3).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la respuesta inmunol\u00f3gica por la inmunoterapia con dermatophagoides pteronyssinus. relaci\u00f3n con la eficacia cl\u00ednica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la respuesta inmunol\u00f3gica por la inmunoterapia con dermatophagoides pteronyssinus. relaci\u00f3n con la eficacia cl\u00ednica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Vict\u00f3ria Cardona Dahl <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Merc\u00e9 Corominas S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li> Martin mateos Mar\u00eda  asunci\u00f3n (vocal)<\/li>\n<li>enric Buendia gr\u00ed\u00a0cia (vocal)<\/li>\n<li> Torres rodr\u00edguez josep Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Vict\u00f3ria Cardona Dahl Antecedentes las enfermedades al\u00e9rgicas se han asociado a un desequilibrio inmunol\u00f3gico consistente en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[63058,63055,63057,63056,13703,33890],"class_list":["post-20777","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-enric-buendia-gri-cia","tag-m-victaria-cardona-dahl","tag-martin-mateos-maria-asuncion","tag-merca-corominas-sanchez","tag-miquel-vilardell-tarres","tag-torres-rodriguez-josep-maria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=20777"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20777\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=20777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=20777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=20777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}