{"id":20813,"date":"2018-03-09T09:10:19","date_gmt":"2018-03-09T09:10:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/prenatal-suffering-and-genetic-variability-as-causative-factors-of-schizophrenia-and-schizophrenia-spectrum-disorders-phenotype\/"},"modified":"2018-03-09T09:10:19","modified_gmt":"2018-03-09T09:10:19","slug":"prenatal-suffering-and-genetic-variability-as-causative-factors-of-schizophrenia-and-schizophrenia-spectrum-disorders-phenotype","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/prenatal-suffering-and-genetic-variability-as-causative-factors-of-schizophrenia-and-schizophrenia-spectrum-disorders-phenotype\/","title":{"rendered":"Prenatal suffering and genetic variability as causative factors of schizophrenia and schizophrenia spectrum disorders phenotype"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Araceli Rosa De La Cruz <\/strong><\/h2>\n<p>El objetivo general de la presente tesis fue estudiar marcadores de sufrimiento prenatal y genes candidatos como factores biol\u00f3gicos de riesgo en la esquizofrenia y en trastornos del espectro esquizofreniforme (tee).  la mayor frecuencia de anomal\u00edas dermatogl\u00edficas y de pliegues de flexi\u00f3n palmar an\u00f3malos en pacientes con esquizofrenia y tee parece confirmar la existencia de sufrimiento intrauterino en una proporci\u00f3n de estos individuos y por tanto en la etiopatogenia de estos trastornos. De manera espec\u00edfica, los estudios dermatogl\u00edficos llevados a cabo en muestras de gemelos y de hermanos discordantes para la enfermedad, investigadas en esta tesis han corrobando la importancia del sufrimiento intrauterino en el riesgo posterior para sufrir estos trastornos.  con respecto al an\u00e1lisis de genes candidatos el presente trabajo ha puesto de manifiesto la utilidad de las dimensiones psicopatol\u00f3gicas para la identificaci\u00f3n de un posible gen candidato en el \u00e1rea 1q21-q22, que se relacionar\u00eda, en hip\u00f3tesis, con la expresi\u00f3n de s\u00edntomas positivos presentes en las psicosis.  asimismo, la variaci\u00f3n gen\u00e9tica en la zona promotora del gen de la il-beta se relacionar\u00eda con la manifestaci\u00f3n de la dimensi\u00f3n depresiva dentro del fenotipo de la esquizofrenia y tee.  por \u00faltimo se ha podido relacionar, de una manera clara, la existencia de una asociaci\u00f3n dosis-efecto, en individuos sanos, entre los genotipos del gen de la comt que participa en la degradaci\u00f3n de las catecolaminas y la funci\u00f3n ejecutiva medida con el wisconsin card sorting test. Esta asociaci\u00f3n no fue encontrada en el grupo de pacientes.  en conclusi\u00f3n, debemos pensar qu ene la esquizofrenia y en los trastornos del espectro esquizofreniforme existe una alteraci\u00f3n en las etapas precoces del desarrollo cerebral en la que el ambiente intrauterino parece jugar un papel a tener en cuenta, manteni\u00e9ndose abierta la hip\u00f3tesis de un neurodesarrollo precozmente alterad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Prenatal suffering and genetic variability as causative factors of schizophrenia and schizophrenia spectrum disorders phenotype<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Prenatal suffering and genetic variability as causative factors of schizophrenia and schizophrenia spectrum disorders phenotype <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Araceli Rosa De La Cruz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lourdes Fa\u00f1an\u00e1s  Saura<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jaume Bertranpetit busquets <\/li>\n<li>jim Van os (vocal)<\/li>\n<li>victor Peralta martin (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Araceli Rosa De La Cruz El objetivo general de la presente tesis fue estudiar marcadores de sufrimiento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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