{"id":20814,"date":"2018-03-09T09:10:19","date_gmt":"2018-03-09T09:10:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-alteraciones-geneticas-en-el-cancer-de-tiroides\/"},"modified":"2018-03-09T09:10:19","modified_gmt":"2018-03-09T09:10:19","slug":"estudio-de-alteraciones-geneticas-en-el-cancer-de-tiroides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-alteraciones-geneticas-en-el-cancer-de-tiroides\/","title":{"rendered":"Estudio de alteraciones gen\u00e9ticas en el c\u00e1ncer de tiroides"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Oriola Ambros <\/strong><\/h2>\n<p>Introducci\u00f3n  el c\u00e1ncer de tiroides, al igual que otras neoplasias, se forma a partir de c\u00e9lulas transformadas que han ganado en capacidad de divisi\u00f3n a causa de alteraciones gen\u00e9ticas. Cuando se empez\u00f3 este trabajo, se sabia que mutaciones en el proto-oncog\u00e9n ret era las responsables del c\u00e1ncer medular de tiroides (cmt) de tipo familiar (men 2), aunque las relaciones genotipo-fenotipo era poco conocidas. Tambi\u00e9n se sabia que mutaciones en los proto-oncogenes ras estaban presentes en fases muy iniciales en el carcinoma papilar (cpt) i en el adenoma folicular de tiroides (aft), y tambi\u00e9n que un 20-40% de los cpt presentan reordenamientos de los proto-oncogenes ret o ntrk1.  objetivos  1,- detecci\u00f3n de mutaciones en el proto-oncog\u00e9n ret en familias espa\u00f1olas afectas de men2. Mejorar el conocimiento de la relaci\u00f3n genotipo-fenotipo.  2,- buscar nuevas alteraciones gen\u00e9ticas en el cpt y el aft, que nos permitan conocer otras causas de ambas neoplasias.  material y m\u00e9todos  estudio del proto-oncogen ret  la poblaci\u00f3n estudiada se ha dividido en dos grupos: 28 casos aparentemente familiares y 108 casos aparentemente espor\u00e1dicos (96 cmt y 12 feocromocitomas). se ha amplificado por pcr y secuenciado los exones, 10, 11, 13, 14, 15 y 16. Cuando hemos encontrado la mutaci\u00f3n, el resto de familiares se ha analizado utilizando alguno de los siguientes m\u00e9todos: enzimas de restricci\u00f3n, polimorfismo de diferente conformaci\u00f3n de cadena sencilla (sscp) y creaci\u00f3n de diana de restricci\u00f3n mediante amplificaci\u00f3n (acrs-pcr).  estudio de alteraciones gen\u00e9ticas en aft y cpt  muestras estudiadas: 21 aft y 15 cpt (tejidos normal y tumoral). Mediante microsat\u00e9lites, hemos estudiado diferentes puntos del genoma para poder detectar p\u00e9rdidas al\u00e9licas (loh), caracter\u00edsticas de los tumores en los cuales los genes supresores de tumor (gst) est\u00e1n implicados. Hemos estudiado 20 microsat\u00e9lites situados en 10 \u00e1reas que corresponden a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de alteraciones gen\u00e9ticas en el c\u00e1ncer de tiroides<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de alteraciones gen\u00e9ticas en el c\u00e1ncer de tiroides <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Oriola Ambros <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Zorzano Olarte<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Palac\u00edn prieto <\/li>\n<li>irene Halperin rabinovich (vocal)<\/li>\n<li>virginia Nunes mart\u00ednez (vocal)<\/li>\n<li>roser Casamitjana abella (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Oriola Ambros Introducci\u00f3n el c\u00e1ncer de tiroides, al igual que otras neoplasias, se forma a partir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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