{"id":20838,"date":"2018-03-09T09:10:21","date_gmt":"2018-03-09T09:10:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-entre-la-protea%c2%adna-relacionada-con-la-parathormona-pthrp-y-la-interleuquina-6-en-la-regulacion-del-remodelado-oseo\/"},"modified":"2018-03-09T09:10:21","modified_gmt":"2018-03-09T09:10:21","slug":"interacciones-entre-la-protea%c2%adna-relacionada-con-la-parathormona-pthrp-y-la-interleuquina-6-en-la-regulacion-del-remodelado-oseo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interacciones-entre-la-protea%c2%adna-relacionada-con-la-parathormona-pthrp-y-la-interleuquina-6-en-la-regulacion-del-remodelado-oseo\/","title":{"rendered":"Interacciones entre la prote\u00edna relacionada con la parathormona (pthrp) y la interleuquina-6 en la regulaci\u00f3n del remodelado \u00f3seo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Guill\u00e9n Viejo <\/strong><\/h2>\n<p>La interleuquina-6 (il-6) parece actuar como mediadora de diversos agentes resortivos y jugar un papel importante en la p\u00e9rdida de masa \u00f3sea en la deficiencia estrog\u00e9nica. Su receptor soluble (sil-6r) ejerce un efecto autoregulador sobre la il-6 que podr\u00eda incidir en su acci\u00f3n osteol\u00edtica. la il-6 se induce por la activaci\u00f3n del factor de transcripci\u00f3n nf-kb, un factor que es activado por varios agentes resortivos, como la parathormona (pth), en los osteoblastos. La prote\u00edna relacionada con la pth (pthrp) ejerce efectos complejos sobre el remodelado \u00f3seo, en parte a trav\u00e9s de otras citoquinas. Hemos analizado la hip\u00f3tesis de que la pthrp podr\u00eda formar parte de un circuito de retroalimentaci\u00f3n para mantener los niveles de il-6 en el entorno \u00f3seo. Hemos encontrado que el fragmento 1-36 y el posible fragmento 107-139 de la pthrp aumentan la expresi\u00f3n de il-6 en c\u00e9lulas de fenotipo osteobl\u00e1stico: de osteosarcoma de rata umr 106 y humano mg-63, y de hueso trabecular humano (hob). En estas c\u00e9lulas, este efecto se aboli\u00f3 con inhibidores del nf-kb.  adem\u00e1s, encontramos que ambos fragmentos activan el complejo nf-kb e inducen la translocaci\u00f3n nuclear del heterod\u00edmero constituyente p65-p50, interfiriendo con la degradaci\u00f3n del inhibidor ikb-alfa citos\u00f3lico, con un patr\u00f3n similar al observado para la inducci\u00f3n de la il-6.  los efectos de ambos fragmentos de la pthrp juntos no fueron mayores que los observados con cada uno por separado. La inducci\u00f3n de la il-6 por la pthrp n- y c-terminal a trav\u00e9s del nf-kb tiene caracter\u00edsticas de un gen de respuesta temprana, y ocurre por un mecanismo dependiente de prote\u00edna quinasa (pk) a o pkc, respectivamente.  por otra parte, tanto la il-6 como el sil-6r, a concentraciones asociadas al aumento del remodelado \u00f3seo, inducen la expresi\u00f3n de la pthrp y su propia expresi\u00f3n en los hob.  nuestros hallazgos demuestran que ambos fragmentos de la pthrp inducen la expresi\u00f3n de il-6 e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacciones entre la prote\u00edna relacionada con la parathormona (pthrp) y la interleuquina-6 en la regulaci\u00f3n del remodelado \u00f3seo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacciones entre la prote\u00edna relacionada con la parathormona (pthrp) y la interleuquina-6 en la regulaci\u00f3n del remodelado \u00f3seo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Guill\u00e9n Viejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Esbrit Arguelles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristina Casals carro <\/li>\n<li> Castrillo diez Jos\u00e9 Luis (vocal)<\/li>\n<li>Luis Munuera Martinez (vocal)<\/li>\n<li>Jes\u00fas Hurtado s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Guill\u00e9n Viejo La interleuquina-6 (il-6) parece actuar como mediadora de diversos agentes resortivos y jugar un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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