{"id":20855,"date":"2018-03-09T09:10:23","date_gmt":"2018-03-09T09:10:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/segundo-trasplante-autologo-acondicionado-con-cbv-en-mieloma-multiple-analisis-de-toxicidad-y-eficacia\/"},"modified":"2018-03-09T09:10:23","modified_gmt":"2018-03-09T09:10:23","slug":"segundo-trasplante-autologo-acondicionado-con-cbv-en-mieloma-multiple-analisis-de-toxicidad-y-eficacia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/segundo-trasplante-autologo-acondicionado-con-cbv-en-mieloma-multiple-analisis-de-toxicidad-y-eficacia\/","title":{"rendered":"Segundo trasplante autologo acondicionado con cbv en mieloma multiple: an\u00e1lisis de toxicidad y eficacia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Grande Garc\u00eda <\/strong><\/h2>\n<p>Entre 1994 y 1998, 88 enfermos de mieloma m\u00faltiple (mm) con edad media de 55 a\u00f1os en situaci\u00f3n de respuesta despu\u00e9s de un primer trasplante aut\u00f3logo de progenitores hempoy\u00e9ticos (taph) acondicionado con melfal\u00e1n 200 mg\/m2 (mel200) han sido tratados con un segundo taph acondicionado con el r\u00e9gimen cbv. Del registro nacional de trasplante en mm se ha seleccionado un grupo control constituido por 209 pacientes tratados solo con un taph acondicionado con mel200 para comparar los resultados.  despu\u00e9s del primer trasplante (mel200-taph1), 27 pacientes (31%) estaban en remisi\u00f3n completa (rc) con inmunofijaci\u00f3n (if) negativa. De 48 enfermos evaluables en remisi\u00f3n completa (rp) despu\u00e9s de mel200-taph1,16 (33%) alcanzaron rc con el segundo trasplante (cbv-taph2). La tasa final de rc en los 78 pacientes evaluables por los criterios del ebmt (excluidos 8 mm no secretores y 2 casos sin if disponible) fue del 53,8%. Con una mediana de seguimiento de 50 meses, la probabilidad acumulada de supervivencia a los 5 a\u00f1os fue del 55% (ic 95%, 43% -67%) y la de supervivencia libre de evento (sle) del 28% (ic 95%, 15% -39%).  la mortalidad relacionada con cbv-taph2 fue del 3,4% (3 pacientes fallecieron por neumon\u00eda interstical peritrasplante). No hubo ning\u00fan fracaso de injerto y los tiempos de hospitalizaci\u00f3n, recuperaci\u00f3n de neutr\u00f3filos y de plaquetas fueron similares o algo mejores que con mel200-taph1.  el factor pron\u00f3stico favorable m\u00e1s importante para la supervivencia global (sg) y para la sle fue el estado de rc despu\u00e9s de cbv-taph2. No se encontraron diferencias cuando se compar\u00f3 la supervivencia entre los casos que obtuvieron rc despu\u00e9s de mel200-taph1 con los casos en rp despu\u00e9s de mel200-taph1 y que alcanzaron rc despu\u00e9s de cbv-taph2.  el estudio multivariable evidenci\u00f3 mejor perspectiva de sg y sle en los pacientes tratados con doble taph que en el grupo control tratado con un \u00fanico taph. Sin embargo, en la comparaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Segundo trasplante autologo acondicionado con cbv en mieloma multiple: an\u00e1lisis de toxicidad y eficacia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Segundo trasplante autologo acondicionado con cbv en mieloma multiple: an\u00e1lisis de toxicidad y eficacia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Grande Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Lahuerta Palacios Juan  Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fern\u00e1ndez rodr\u00edguez Manuel nicol\u00e1s <\/li>\n<li>eulogio Conde garcia (vocal)<\/li>\n<li>angela Figuera alvarez (vocal)<\/li>\n<li>joaquin Martinez lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Grande Garc\u00eda Entre 1994 y 1998, 88 enfermos de mieloma m\u00faltiple (mm) con edad media de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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