{"id":20856,"date":"2018-03-09T09:10:23","date_gmt":"2018-03-09T09:10:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-cxcr4-y-sdf-1-en-linfocitos-y-celulas-dendra%c2%adticas-implicaciones-por-el-vih\/"},"modified":"2018-03-09T09:10:23","modified_gmt":"2018-03-09T09:10:23","slug":"expresion-de-cxcr4-y-sdf-1-en-linfocitos-y-celulas-dendra%c2%adticas-implicaciones-por-el-vih","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-cxcr4-y-sdf-1-en-linfocitos-y-celulas-dendra%c2%adticas-implicaciones-por-el-vih\/","title":{"rendered":"Expresi\u00f3n de cxcr4 y sdf-1 en linfocitos y c\u00e9lulas dendr\u00edticas. implicaciones por el vih"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Mercedes Bermejo Herrero <\/strong><\/h2>\n<p>Cxcr4 y ccr5 son los principales correceptores del vih. A pesar de que cxcr4 est\u00e1 muy distribuido, los virus r5 predominan en las fases tempranas de la infecci\u00f3n. Se ha demostrado que las c\u00e9lulas epiteliales producen la quimiocina sdf-1, la cual regula negativamente la expresi\u00f3n de cxcr4 en las c\u00e9lulas de alrededor. Esta es probablemente la raz\u00f3n por la que las c\u00e9lulas de langerhans y las c\u00e9lulas dendr\u00edticas de la piel expresan cxcr4 a nivel intracelular.  esto explicar\u00eda la transmisi\u00f3n preferencial de cepas r5 a trav\u00e9s del contacto sexual, sin embargo los mecanismos involucrados en la resistencia a la infecci\u00f3n de los linfocitos por cepas x4 inmediatamente despu\u00e9s de la transmisi\u00f3n, incluso cuando ocurre a trav\u00e9s de la ruta intravenosa no est\u00e1n totalmente comprendidos. En particular hay estudios controvertidos respecto a la expresi\u00f3n de cxcr4 y a la activaci\u00f3n. Para intentar comprender los mecanismos de propagaci\u00f3n de cepas x4 en linfocitos nosotros estudiamos la expresi\u00f3n de cxcr4 en linfocitos reci\u00e9n aislados sin activar manteni\u00e9ndolos en cultivo y su regulaci\u00f3n por diferentes est\u00edmulos. Como sdf-1 regula negativamente la expresi\u00f3n de cxcr4, estudiamos la expresi\u00f3n de esta quimiocina en diferentes \u00f3rganos linfoides y cultivos de c\u00e9lulas dendr\u00edticas in vitro.  viendo que cxcr4 est\u00e1 presente en una localizaci\u00f3n intracelular en la mayor\u00eda de los linfocitos reci\u00e9n aislados, y se localizan en la superficie s\u00f3lo despu\u00e9s de mantenerlos unas horas en cultivo. La activaci\u00f3n 1 con anti-cd3 y pha regulan negativamente la expresi\u00f3n de cxcr4 en la superficie celular. las c\u00e9lulas dendr\u00edticas situadas en la zona parafolicular, c\u00e9lulas epiteliales de las criptas y subepiteliales por debajo de las criptas con morfolog\u00eda de c\u00e9lulas dendr\u00edticas expresan sdf-1. Las c\u00e9lulas foliculares dendr\u00edticas no expresan sdf-1. El sdf-1 que expresan las c\u00e9lulas dendr\u00edticas es funcional.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de cxcr4 y sdf-1 en linfocitos y c\u00e9lulas dendr\u00edticas. implicaciones por el vih<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de cxcr4 y sdf-1 en linfocitos y c\u00e9lulas dendr\u00edticas. implicaciones por el vih <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Mercedes Bermejo Herrero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Alcami Pertejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>Jos\u00e9 Luis Pablos alvarez (vocal)<\/li>\n<li>m. angeles Mu\u00f1oz fernandez (vocal)<\/li>\n<li>Antonio Caruz arcos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Mercedes Bermejo Herrero Cxcr4 y ccr5 son los principales correceptores del vih. A pesar de que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[63251,14425,22623,62668,30047,63250],"class_list":["post-20856","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-caruz-arcos","tag-francisco-sanchez-madrid","tag-jose-alcami-pertejo","tag-jose-luis-pablos-alvarez","tag-m-angeles-munoz-fernandez","tag-maria-mercedes-bermejo-herrero"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20856","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=20856"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20856\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=20856"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=20856"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=20856"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}