{"id":20901,"date":"2018-03-09T09:10:27","date_gmt":"2018-03-09T09:10:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-map-quinasas-por-cannabinoides-mecanismo-e-implicacion-en-el-control-del-destino-celular\/"},"modified":"2018-03-09T09:10:27","modified_gmt":"2018-03-09T09:10:27","slug":"regulacion-de-map-quinasas-por-cannabinoides-mecanismo-e-implicacion-en-el-control-del-destino-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-map-quinasas-por-cannabinoides-mecanismo-e-implicacion-en-el-control-del-destino-celular\/","title":{"rendered":"Regulaci\u00f3n de map quinasas por cannabinoides: mecanismo e implicaci\u00f3n en el control del destino celular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Rueda Fern\u00e1ndez <\/strong><\/h2>\n<p>Los cannabinoides, compuestos activos de la marihuana (cannabis sativa) y sus derivados, son considerados en la actualidad sustancias con un posible potencial terap\u00e9utico. Durante los \u00faltimos a\u00f1os se ha descrito la existencia en el organismo del sistema endocannabionoide, constituido por lignados end\u00f3genos, receptores espec\u00edficos, as\u00ed como mecanismos de terminaci\u00f3n de la se\u00f1al. A nivel molecular, se ha descrito estos compuestos modulan ciertos canales i\u00f3nicos y la actividad adenilil ciclasa. Sin embargo, a pesar de que se ha demostrado que los cannabinoides poseen efectos inhibidores de la proliferaci\u00f3n y apopt\u00f3ticos, se sabe poco sobre los mecanismos mediante los cuales la activaci\u00f3n los receptores para cannabinoides conduce a la regulaci\u00f3n del destino celular.  las cascadas map quinasa, y en concreto la ruta erk, se sbe desempe\u00f1an un papel crucial en la regulaci\u00f3n de este tipo de respuestas, de manera que se ha abordado el estudio de a trav\u00e9s de qu\u00e9 cascadas de transducci\u00f3n de se\u00f1ales los cannabinoides controlan la actividad de esta v\u00eda, y de d\u00f3mo ello redunda en la decisi\u00f3n supervivencia\/muerte celular, habi\u00e9ndose demostrado que la cascada erk es modulada por cannabinoides a trav\u00e9s de un mecanismo dependiente de sus receptores espec\u00edficos, las subunidades betagamma de prote\u00ednas g heterotrim\u00e9ricas y pi3k.  por otro lado, se ha demostrado por primera vez que los cannabinoides tienen efectos inhibitorios sobre la diferenciaci\u00f3n neuronal, dependiendo este efecto tambi\u00e9n de la modulaci\u00f3n de la actividad erk.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de map quinasas por cannabinoides: mecanismo e implicaci\u00f3n en el control del destino celular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de map quinasas por cannabinoides: mecanismo e implicaci\u00f3n en el control del destino celular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Rueda Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Guzm\u00e1n Pastor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel Fabregat romero <\/li>\n<li> Merida san roman isabel (vocal)<\/li>\n<li>thierry Levade (vocal)<\/li>\n<li>in\u00e9s D\u00edaz-laviada marturet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Rueda Fern\u00e1ndez Los cannabinoides, compuestos activos de la marihuana (cannabis sativa) y sus derivados, son considerados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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