{"id":20921,"date":"2018-03-09T09:10:28","date_gmt":"2018-03-09T09:10:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-estructura-tridimensional-y-de-la-dinamica-de-oligosacaridos-modelos-de-glicosaminoglicanos-mediante-rmn-y-simulaciones-de-dinamica-molecular\/"},"modified":"2018-03-09T09:10:28","modified_gmt":"2018-03-09T09:10:28","slug":"estudio-de-la-estructura-tridimensional-y-de-la-dinamica-de-oligosacaridos-modelos-de-glicosaminoglicanos-mediante-rmn-y-simulaciones-de-dinamica-molecular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/estudio-de-la-estructura-tridimensional-y-de-la-dinamica-de-oligosacaridos-modelos-de-glicosaminoglicanos-mediante-rmn-y-simulaciones-de-dinamica-molecular\/","title":{"rendered":"Estudio de la estructura tridimensional y de la din\u00e1mica de oligosacaridos modelos de glicosaminoglicanos mediante rmn y simulaciones de din\u00e1mica molecular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Angulo \u00e1lvarez <\/strong><\/h2>\n<p>En esta tesis doctoral se presentan los estudios estructurales de oligosac\u00e1ridos modelos de glicosaminoglicanos (gags) que se han sintetizado para abordar el estudio de las bases moleculares de la activaci\u00f3n de los factores de crecimiento para fibroplastos (fgfs). Se han resuelto las estructuras tridimensionales de 4 hexasac\u00e1ridos con diferentes patrones de sulfataci\u00f3n mediante espectroscop\u00eda de rmn y modelizaci\u00f3n molecular. Mediante la detecci\u00f3n de se\u00f1ales de efecto overhauser nuclear (noe), y las predicciones te\u00f3ricas de la mec\u00e1nica molecular, se ha podido determinar una estructura global en t\u00e9rminos de una h\u00e9lice a derechas a nivel del esqueleto covalente oligosacar\u00eddico, similar para los 4 hexasac\u00e1ridos y an\u00e1loga a la descrita paral a heparina natural. El an\u00e1lisis de constantes de acoplamiento vecinales homonucleares ha evidenciado un equilibrio de conf\u00f3rmeros para los anillos de \u00e1cido idur\u00f3nico constituyentes. los datos de relajaci\u00f3n homo- y heteronuclear han puesto de manifiesto una orientaci\u00f3n hidrodi\u00e1mica anisotr\u00f3pica de estos productos en disoluci\u00f3n, as\u00ed como una marcada rigidez de dicha conformaci\u00f3n helicoidal. Para el estudio din\u00e1mico de estas mol\u00e9culas se ha realizado una investigaci\u00f3n metodol\u00f3gica de distintas condiciones de simulaci\u00f3n de din\u00e1mica molecular. Para el acuerdo con los datos de rmn ha sido necesaria la aplicaci\u00f3n del ametodolog\u00eda part\u00edcula. malla de ewald en dichas simulaciones. Esta metodolog\u00eda ha permitido la obtenci\u00f3n de din\u00e1micas moleculares en las que los conf\u00f3rmeros del anillo de idur\u00f3nico son estables, revelando la importancia del tratamiento electrost\u00e1tico adecuado para estos sistemas moleculares con una elevada carga negativa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la estructura tridimensional y de la din\u00e1mica de oligosacaridos modelos de glicosaminoglicanos mediante rmn y simulaciones de din\u00e1mica molecular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la estructura tridimensional y de la din\u00e1mica de oligosacaridos modelos de glicosaminoglicanos mediante rmn y simulaciones de din\u00e1mica molecular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Angulo \u00e1lvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Manuel Nieto Mesa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Mendoza sanz Javierde <\/li>\n<li>Jos\u00e9 Fuentes mota (vocal)<\/li>\n<li>Manuel Rico sorompas (vocal)<\/li>\n<li>Jes\u00fas Jim\u00e9nez-barbero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Angulo \u00e1lvarez En esta tesis doctoral se presentan los estudios estructurales de oligosac\u00e1ridos modelos de glicosaminoglicanos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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