{"id":20944,"date":"2018-03-09T09:10:30","date_gmt":"2018-03-09T09:10:30","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-actividad-biologica-del-factor-derivado-del-epitelio-pigmentado-pedf\/"},"modified":"2018-03-09T09:10:30","modified_gmt":"2018-03-09T09:10:30","slug":"estudio-de-la-actividad-biologica-del-factor-derivado-del-epitelio-pigmentado-pedf","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/estudio-de-la-actividad-biologica-del-factor-derivado-del-epitelio-pigmentado-pedf\/","title":{"rendered":"Estudio de la actividad biol\u00f3gica del factor derivado del epitelio pigmentado (pedf)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> I\u00f1igo Izal Azcarate <\/strong><\/h2>\n<p>El factor derivado de lepitelio pigmentado (pedf) es una glicoprote\u00edna miembro de la superfamilia de las serpinas. Se describi\u00f3 inicialmente como producto de secreci\u00f3n del epitelio pigmentado de la retina encargado de promover el desarrollo de la retina neuronal. Relacionado con esto, se han derivado varias actividades como factor neurotr\u00f3fico y neuroprotector, entre ellas la inducci\u00f3n de diferenciaci\u00f3n de c\u00e9lulas de retinoblastoma (y-79), la protecci\u00f3n frente a la toxicidad inducida por glutamato en neuronas cerebelares y en motoneuronas, la protecci\u00f3n frente a la toxicidad inducida por per\u00f3xicidad inducida por per\u00f3xido de hidr\u00f3geno en neuronas de la retina o la protecci\u00f3n morfol\u00f3gica y funcional de fotorreceptores. Recientemente se ha descrito una actividad como factor inhibidor de la formaci\u00f3n de vasos (angiog\u00e9nesis) y como inhibidor del crecimiento tumoral.  las propiedades superficiales de carga de pedf son de particular relevancia, al permitirle su uni\u00f3n al receptor en la superficie celular. No obstante tambi\u00e9n confieren a la prote\u00edna la capacidad de unir glicosaminoglicanos, componentes de la matriz extracelular. Se ha llegado a proponer mediante modelizaci\u00f3n molecular un sitio de uni\u00f3n compuesto por amino\u00e1cidos de car\u00e1cter b\u00e1sico. La presencia de glicosaminoglicanos fuenciona meramente como soporte celular, ha sido descrita su participaci\u00f3n en la actividad de moleculas se\u00f1alizadoras extracelulares.  hemos descrito un protocolo de purificaci\u00f3n de pedf sobreexpresado en c\u00e9lulas eucariotas (bhk) mediante doble cormatograf\u00eda de intercambio cati\u00f3nico-ani\u00f3nico, as\u00ed como un ensayo elisa para determinar la concentraci\u00f3n de pedf. Hemos sintetizado p\u00e9ptido componentes de la zona neurotr\u00f3fica de la prote\u00edna y hemos constru\u00eddo sueros frente a \u00e9stos. Los sueros han sido caracterizados mediante western blot y elisa.  se ha realizado el an\u00e1lisis, mediante mutag\u00e9nesis dirigida, de la uni\u00f3n de pedf a glic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la actividad biol\u00f3gica del factor derivado del epitelio pigmentado (pedf)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la actividad biol\u00f3gica del factor derivado del epitelio pigmentado (pedf) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 I\u00f1igo Izal Azcarate <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Alberto P\u00e9rez Mediavilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: natalia Mar\u00eda Lopez moratalia <\/li>\n<li>i\u00f1igo Lasa uzcudun (vocal)<\/li>\n<li>Elena Alberdi alfonso (vocal)<\/li>\n<li>Antonio Mart\u00ednez mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de I\u00f1igo Izal Azcarate El factor derivado de lepitelio pigmentado (pedf) es una glicoprote\u00edna miembro de la superfamilia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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