{"id":20981,"date":"2018-03-09T09:10:33","date_gmt":"2018-03-09T09:10:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enfermedad-cela%c2%adaca-marcadores-serologicos-y-de-predisposicion-genetica-aspectos-cla%c2%adnicos-y-poblaciones-de-riesgo\/"},"modified":"2018-03-09T09:10:33","modified_gmt":"2018-03-09T09:10:33","slug":"enfermedad-cela%c2%adaca-marcadores-serologicos-y-de-predisposicion-genetica-aspectos-cla%c2%adnicos-y-poblaciones-de-riesgo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-clinica\/enfermedad-cela%c2%adaca-marcadores-serologicos-y-de-predisposicion-genetica-aspectos-cla%c2%adnicos-y-poblaciones-de-riesgo\/","title":{"rendered":"Enfermedad cel\u00edaca: marcadores serol\u00f3gicos y de predisposici\u00f3n gen\u00e9tica, aspectos cl\u00ednicos y poblaciones de riesgo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carme Farre Masip <\/strong><\/h2>\n<p>La enfermedad cel\u00edaca (ec) es un intolerancia al gluten de car\u00e1cter permanente que condiciona en individuos gen\u00e9ticamente predispuestos una lesi\u00f3n inflamatoria de la mucosa del intestino delgado superior. La lesi\u00f3n histol\u00f3gica se relaciona con una respuesta inmune anormal de las c\u00e9lulas t a determinados p\u00e9ptidos de gliadina y se caracteriza por un aumento del infiltrado linfocitario, una hiperplasia de criptas y una atrofia vellositaria intestinal. La activaci\u00f3n de la ec est\u00e1 gen\u00e9ticamente restringida a los portadores de los alelos hla-dq2\/dq8 que codifican las prote\u00ednas dim\u00e9ricas presentadoras de los p\u00e9ptidos de gliadina modificados enzim\u00e1ticamente por la transglutaminasa tisular a las c\u00e9lulas tcr alfabeta+productoras de citoquinas inflamatorias. La respuesta humoral con producci\u00f3n de autoanticuerpos espec\u00edficos contra la transglutaminasa se explica a trav\u00e9s del reconocimiento del reconocimiento del complejo p\u00e9ptido de gliadina &#8211; transglutaminasa y de la colaboraci\u00f3n entre c\u00e9lulas t y b con producci\u00f3n de autoanticuerpos contra la transglutaminasa dependientes de la ingesta de gluten. La ec es la alteraci\u00f3n cr\u00f3nica mas prevalente (1\/200) e infradiganosticada en nuestro medio debido a la inespecificidad de las formas de presentaci\u00f3n cl\u00ednica. La detecci\u00f3n es serol\u00f3gica a trav\u00e9s de los anticuerpos antiendomisio (aea) o antitransglutaminasa (actgt) de clase iga i el diagn\u00f3stico es histol\u00f3gico. El tratamiento consiste en una estricta y permanente dieta sin gluten (dsg), lo que comporta una remisi\u00f3n de la cl\u00ednica y de la lesi\u00f3n histol\u00f3gica, as\u00ed como una negativizaci\u00f3n de los marcadores serol\u00f3gicos.     los tres grandes objetivos de esta tesis son:     1,- la optimizaci\u00f3n de los recursos del laboratorio cl\u00ednico en la detecci\u00f3n de la ec.     2,- el estudio de la ec en poblaciones de riesgo.     3,- el estudio de la relaci\u00f3n entre la ec no tratada y el riesgo de linfoma.     se eval\u00faan los marcadores serol\u00f3gicos de la ec<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Enfermedad cel\u00edaca: marcadores serol\u00f3gicos y de predisposici\u00f3n gen\u00e9tica, aspectos cl\u00ednicos y poblaciones de riesgo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Enfermedad cel\u00edaca: marcadores serol\u00f3gicos y de predisposici\u00f3n gen\u00e9tica, aspectos cl\u00ednicos y poblaciones de riesgo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carme Farre Masip <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Esteve Comas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Llobera sande <\/li>\n<li>Fernando Fern\u00e1ndez ba\u00f1ares (vocal)<\/li>\n<li>Rafael Jimenez gonzalez (vocal)<\/li>\n<li> Cus\u00ed sanchez m. victoria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carme Farre Masip La enfermedad cel\u00edaca (ec) es un intolerancia al gluten de car\u00e1cter permanente que condiciona [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,5531,2612,1176,384],"tags":[63568,63571,63570,63569,259,1201],"class_list":["post-20981","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-fisiologia-gastrointestinal","category-inmunoquimica","category-nutrientes","category-patologia-clinica","tag-carme-farre-masip","tag-cusi-sanchez-m-victoria","tag-fernando-fernandez-banares","tag-maria-esteve-comas","tag-miquel-llobera-sande","tag-rafael-jimenez-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=20981"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/20981\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=20981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=20981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=20981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}