{"id":21012,"date":"2018-03-09T09:10:35","date_gmt":"2018-03-09T09:10:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-de-la-glucosa-6-fosfato-deshidrogenasa-en-la-neuroproteccion-frente-al-estres-nitrosativo\/"},"modified":"2018-03-09T09:10:35","modified_gmt":"2018-03-09T09:10:35","slug":"funcion-de-la-glucosa-6-fosfato-deshidrogenasa-en-la-neuroproteccion-frente-al-estres-nitrosativo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/funcion-de-la-glucosa-6-fosfato-deshidrogenasa-en-la-neuroproteccion-frente-al-estres-nitrosativo\/","title":{"rendered":"Funci\u00f3n de la glucosa-6-fosfato deshidrogenasa en la neuroprotecci\u00f3n frente al estr\u00e9s nitrosativo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paula Garc\u00eda Nogales <\/strong><\/h2>\n<p>El \u00f3xido n\u00edtrico (no) es un radical libre, altamente difusible y de corta vida media que desempe\u00f1a diversas e importantes funciones biol\u00f3gicas. Sin embargo, en ciertas condiciones patol\u00f3gicas, la s\u00edntesis excesiva de \u00f3xido n\u00edtrico (estr\u00e9s nitrosativo) da lugar a la inmediata reacci\u00f3n de este radical con el ani\u00f3n super\u00f3xido para formar el ani\u00f3n peroxinitrito (onoo-). Tanto el \u00f3xido n\u00edtrico como el peroxinitrito son potentes agentes oxidantes su sulfhidrilos, y, por tanto, del antioxidante mayoritario glutati\u00f3n. La capacidad celular para mantener la concentraci\u00f3n intracelular de glutation en su forma reducida parece ser determinante para la supervivencia celular en condiciones de estr\u00e9s nitrosativo.  en base a los estudios realziados con anterioridad, la idea universalmente extendida es que el peroxinitrito es el derivado neurot\u00f3xico del \u00f3xido n\u00edtrico. Sin embargo, los resultados presentados en esta tesis ponen de manifiesto por vez primera que la producci\u00f3n de peroxinitrito no est\u00e1 necesariamente asociada a la muerte neuronal por estr\u00e9s nitrosativo. Al contrario, nuestros resultados demuestran que a concentraciones compatibles con las fisiol\u00f3gicas y, al menos de modo transitorio, el peroxinitrito protege a las neuronas frente al da\u00f1o causado por el exceso de \u00f3xido n\u00edtrico. Adem\u00e1s, en este trabajo se demuestra que la utilizaci\u00f3n de glucosa a trav\u00e9s del ciclo de las pentosas fosfato representa una v\u00eda metab\u00f3lica esencial en dicha protecci\u00f3n. as\u00ed, la actividad de la glucosa-6-fosfato deshidrogenasa (g6pd), enzima limitante de dicho ciclo, se activa por peroxinitrito, tanto ex\u00f3geno como end\u00f3geno, lo que causa un aumento en la producci\u00f3n de nadph que proprociona el poder reductor necesario para la regeneraci\u00f3n del glutati\u00f3n. De esta forma, proponemos que la formaci\u00f3n de peroxinitrito podr\u00eda representar una nueva se\u00f1al de alarma asociada al estr\u00e9s nitrosativo encargada de activar este potente sistema an<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funci\u00f3n de la glucosa-6-fosfato deshidrogenasa en la neuroprotecci\u00f3n frente al estr\u00e9s nitrosativo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funci\u00f3n de la glucosa-6-fosfato deshidrogenasa en la neuroprotecci\u00f3n frente al estr\u00e9s nitrosativo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paula Garc\u00eda Nogales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Pedro Bola\u00f1os Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Medina jimenez <\/li>\n<li>Carlos Vicario abejon (vocal)<\/li>\n<li>ralf Dringen (vocal)<\/li>\n<li>ignacio Lizasoain hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paula Garc\u00eda Nogales El \u00f3xido n\u00edtrico (no) es un radical libre, altamente difusible y de corta vida [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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