{"id":21022,"date":"2018-03-09T09:10:36","date_gmt":"2018-03-09T09:10:36","guid":{"rendered":""},"modified":"2018-03-09T09:10:36","modified_gmt":"2018-03-09T09:10:36","slug":"factores-pronosticos-en-el-cancer-de-pulmon-estudio-morfometrico-de-la-angiogenesis-tumoral-y-de-su-modulacion-mediada-por-la-sa%c2%adntesis-del-oxido-na%c2%adtrico-y-el-factor-de-crecimiento-vascula","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-pronosticos-en-el-cancer-de-pulmon-estudio-morfometrico-de-la-angiogenesis-tumoral-y-de-su-modulacion-mediada-por-la-sa%c2%adntesis-del-oxido-na%c2%adtrico-y-el-factor-de-crecimiento-vascula\/","title":{"rendered":"Factores pron\u00f3sticos en el c\u00e1ncer de pulm\u00f3n: estudio morfom\u00e9trico de la angiog\u00e9nesis tumoral y de su modulaci\u00f3n mediada por la s\u00edntesis del \u00f3xido n\u00edtrico y el factor de crecimiento vascular vegf. an\u00e1lisis de las expresiones de las prote\u00ednas supresoras de tumores p53 y p21walf1"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rubio Mart\u00ednez Luis Alberto <\/strong><\/h2>\n<p>El tratamiento del c\u00e1ncer de pulm\u00f3n de establecen en base a diferentes estrategias, siendo la m\u00e1s definitiva el tratamiento quir\u00fargico radical de la lesi\u00f3n original. Sin embargo, la cirug\u00eda se aplica exclusivamente en pacientes con tumores en estadios i iniciales. De ellos, m\u00e1s del 0% no supera los 5 a\u00f1os de vida. El objetivo de este estudio es la b\u00fasqueda de nuevos factores pron\u00f3sticos que ayuden a identificar al grupo de pacientes con un mayor riesgo de muerte asociado y en los que una terapia adyuvante ser\u00eda beneficiosa.  con este fin, se analizaron 103 casos de tumores nsclc en estadios iniciales i (t1\/t2n0m0) diagnosticados e intervenidos en el hospital universitario la fe entre los a\u00f1os 1992 y 1996, con un seguimiento cl\u00ednico superior a 5 a\u00f1os. En primer lugar, se estudiaron las variables cl\u00ednico-patol\u00f3gicas: tipo tumoral, grado de diferenciaci\u00f3n, sintomatolog\u00eda, tama\u00f1o tumoral, par\u00e1metro t, sexo y edad. En segundo lugar, se realiz\u00f3 un estudio morfom\u00e9trico automatizado de la angiog\u00e9nesis tumoral mediante un analizador de im\u00e1genes. tambi\u00e9n se analizaron las expresiones inmunohistoqu\u00edmicas de los factores biol\u00f3gicos vegf e inos (sintasa del \u00f3xido n\u00edtrico inducible). Por \u00faltimo, se valor\u00f3 la expresi\u00f3n de las prote\u00ednas supresoras de tumores p53 y p21waf1.  los factores analizados en el an\u00e1lisis estad\u00edstico univariable (kaplan-meier) que demuestran una correlaci\u00f3n con una menor de supervivencia son: un tama\u00f1o tumoral &gt;3 cm, casos en el estadio t2, una angiog\u00e9nesis elevada y la no expresi\u00f3n de la prote\u00edna p21waf1. Estos factores con significaci\u00f3n pron\u00f3stica fueron incluidos en el an\u00e1lisis multivariante (modelo de cox), mostrando como \u00fanicos factores pron\u00f3sticos independientes en relaci\u00f3n a la supervivencia: el tama\u00f1o tumoral (p=0,0063), la angiog\u00e9nesis (p=0,0271) y la expresi\u00f3n del p21waf1 (p=0,0478); siendo, en este sentido, el factor m\u00e1s importante el tama\u00f1o tumoral, con un riesgo de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores pron\u00f3sticos en el c\u00e1ncer de pulm\u00f3n: estudio morfom\u00e9trico de la angiog\u00e9nesis tumoral y de su modulaci\u00f3n mediada por la s\u00edntesis del \u00f3xido n\u00edtrico y el factor de crecimiento vascular vegf. an\u00e1lisis de las expresiones de las prote\u00ednas supresoras de tumores p53 y p21walf1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores pron\u00f3sticos en el c\u00e1ncer de pulm\u00f3n: estudio morfom\u00e9trico de la angiog\u00e9nesis tumoral y de su modulaci\u00f3n mediada por la s\u00edntesis del \u00f3xido n\u00edtrico y el factor de crecimiento vascular vegf. an\u00e1lisis de las expresiones de las prote\u00ednas supresoras de tumores p53 y p21walf1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rubio Mart\u00ednez Luis Alberto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Jose Vera Sempere<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: samuel Navarro fos <\/li>\n<li>Carlos Gamallo amat (vocal)<\/li>\n<li>Emilio Fernandez alvarez (vocal)<\/li>\n<li>Jes\u00fas Garcia foncillas lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rubio Mart\u00ednez Luis Alberto El tratamiento del c\u00e1ncer de pulm\u00f3n de establecen en base a diferentes estrategias, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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