{"id":21035,"date":"2018-03-09T09:10:37","date_gmt":"2018-03-09T09:10:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-por-citometria-de-flujo-de-subpoblaciones-linfocitarias-y-de-celulas-progenitoras-hematopoyeticas-en-sangre-de-cordon-umbilical-de-prematuros\/"},"modified":"2018-03-09T09:10:37","modified_gmt":"2018-03-09T09:10:37","slug":"estudio-por-citometria-de-flujo-de-subpoblaciones-linfocitarias-y-de-celulas-progenitoras-hematopoyeticas-en-sangre-de-cordon-umbilical-de-prematuros","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-por-citometria-de-flujo-de-subpoblaciones-linfocitarias-y-de-celulas-progenitoras-hematopoyeticas-en-sangre-de-cordon-umbilical-de-prematuros\/","title":{"rendered":"Estudio por citometr\u00eda de flujo de subpoblaciones linfocitarias y de c\u00e9lulas progenitoras hematopoy\u00e9ticas en sangre de cord\u00f3n umbilical de prematuros"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aurea Cervera Bravo <\/strong><\/h2>\n<p>Justificaci\u00f3n  la sangre de cord\u00f3n umbilical (scu) de prematuros (pt) sigue siendo un producto de desecho por lo que se desconocen sus propiedades y su posible utilidad cl\u00ednica.  objetivos  estudiar el inmunofenotipo linfocitario y de c\u00e9lulas progenitoras hematopoy\u00e9ticas (cph) de la scu criopreservada de pt compar\u00e1ndola con un grupo control de reci\u00e9n nacidos a t\u00e9rmino (rnt), ver como influyen ciertas caracter\u00edsticas cl\u00ednicas y problemas obst\u00e9tricos en las distribuciones celulares y estimar la viabilidad de su empleo como fuente de cph para trasplante.  material y m\u00e9todos  se estudian 43 muestras criopreservadas de pt y 40 de rnt por citometr\u00eda de flujo de 4 colores, empleando 22 ac., Monoclonales diferentes. Se recogieron datos de somatometr\u00eda del rn, sexo y problemas obst\u00e9tricos y se estim\u00f3 el volumen de scu calculando que era de 23 ml\/1000 g de peso (surbeck 1998). el estudio estad\u00edstico se realiz\u00f3 con programa spss. Para el estudio multivariable se realiz\u00f3 una regresi\u00f3n lineal m\u00faltiple.  resultados  se encontr\u00f3 una gran variabilidad en los resultados, tanto de subpoblaciones linfocitarias como de cph.  subpoblaciones linfocitarias  los pt ten\u00edan mayor porcentaje de c\u00e9lulas sin marcar (77% ten\u00edan m\u00e1s del 10%) por la menor expresi\u00f3n de cd19 en esta poblaci\u00f3n y por tanto, menor porcentaje de linfocitos b. Hab\u00eda diferencias estad\u00edsticamente significativas en las poblaciones: cd19+\/cd10-cd7-, mayor de rnt y en la de c\u00e9lulas nk fetales cd3-cd56+cd16-, y la muy escasa poblaci\u00f3n de linfocitos t de memoria: cd3+cd45ro+ mayor en pt y grandes pt (pt&lt;32 sg) respectivamente. Adem\u00e1s exist\u00eda correlaci\u00f3n negativa con sg para la poblaci\u00f3n de linfocitos t: cd3+cd4+cd8+, p=0,034.  subpoblaciones de cph  no hab\u00eda diferencias significativas entre pt y rnt en el porcentaje ni concentraci\u00f3n de c\u00e9lulas cd34+. Se encontr\u00f3 mayor porcentaje en pt de c\u00e9lulas primitivas (cd34+cd38-, cd34+cd38-cd90dr- y cd3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio por citometr\u00eda de flujo de subpoblaciones linfocitarias y de c\u00e9lulas progenitoras hematopoy\u00e9ticas en sangre de cord\u00f3n umbilical de prematuros<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio por citometr\u00eda de flujo de subpoblaciones linfocitarias y de c\u00e9lulas progenitoras hematopoy\u00e9ticas en sangre de cord\u00f3n umbilical de prematuros <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aurea Cervera Bravo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Madero Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Hern\u00e1ndez <\/li>\n<li> Garc\u00eda del muro Juan (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aurea Cervera Bravo Justificaci\u00f3n la sangre de cord\u00f3n umbilical (scu) de prematuros (pt) sigue siendo un producto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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