{"id":21098,"date":"2003-09-01T00:00:00","date_gmt":"2003-09-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-apoptosis-en-la-nefroesclerosis-hipertensiva\/"},"modified":"2003-09-01T00:00:00","modified_gmt":"2003-09-01T00:00:00","slug":"estudio-de-la-apoptosis-en-la-nefroesclerosis-hipertensiva","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-apoptosis-en-la-nefroesclerosis-hipertensiva\/","title":{"rendered":"Estudio de la apoptosis en la nefroesclerosis hipertensiva"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Soto R\u00edos Miriam Karina <\/strong><\/h2>\n<p>La hta induce, a lo largo de los a\u00f1os, una alteraci\u00f3n de la estructura renal con el consiguiente deterioro de la funci\u00f3n, llegando a la nefroesclerosis hipertensiva (nh), donde es evidente la p\u00e9rdida progresiva de c\u00e9lulas. la importancia de esta rarefacci\u00f3n tisular en el desarrollo de la nh se aborda en este trabajo, con el estudio de la apoptosis en un modelo in vivo de animales hipertensos con reducci\u00f3n de la masa renal. Mediante estudios in vitro investigamos posibles mecanismos implicados en este fen\u00f3meno.  en este trabajo, hemos demostrado que en el establecimiento y desarrollo de la nh un aumento de la tasa de apoptosis que participa activamente en la p\u00e9rdida celular y fibrosis, existiendo una correlaci\u00f3n con el grado de disfunci\u00f3n renal. Estos cambios se asocian con alteraciones en la expresi\u00f3n de algunos genes relacionados con este proceso, concretamente la familia bcl-2.  la administraci\u00f3n de un inhibidor de la eca o de un antagonista de los receptores at1 de la angiotensina ii disminuy\u00f3 la lesi\u00f3n renal y la tasa de apoptosis, sugiriendo, al menos parcialmente, la participaci\u00f3n del sistema renina-angiotensina en este proceso.  mediante estudios in vitro hemos demostrado que las c\u00e9lulas mensagiales procedentes de animales hipertensos adquieren con el desarrollo de la hta y la edad, una mayor susceptibilidad a la apoptosis.  este fen\u00f3meno parece estar relacionado con alteraciones en la expresi\u00f3n de los genes de la familia bcl-2 y de la actividad del factor de transcripci\u00f3n nf-kb.  en resumen, la hta provoca a nivel celular una predisposici\u00f3n a la muerte celular programada o apoptosis. La normalizaci\u00f3n de los niveles tensi\u00f3n arterial es no es suficientemente para controlar la apoptosis tras una reducci\u00f3n marcada de masa renal asociada a hipertensi\u00f3n. Adem\u00e1s, nuestros datos sugieren la existencia de diferencias en los mecanismos moleculares del control de la apoptosis entre c\u00e9lulas mesangiales de anima<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la apoptosis en la nefroesclerosis hipertensiva<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la apoptosis en la nefroesclerosis hipertensiva <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Soto R\u00edos Miriam Karina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Egido De Los Rios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Oya otero <\/li>\n<li>Luis Orte mart\u00ednez (vocal)<\/li>\n<li>Jos\u00e9 Lu\u00f1o fern\u00e1ndez (vocal)<\/li>\n<li>Alberto Ortiz arduan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Soto R\u00edos Miriam Karina La hta induce, a lo largo de los a\u00f1os, una alteraci\u00f3n de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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