{"id":21124,"date":"2003-10-01T00:00:00","date_gmt":"2003-10-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alelos-clase-ii-del-sistema-principal-de-histocompatibilidad-en-la-cardiopata%c2%ada-reumatica\/"},"modified":"2003-10-01T00:00:00","modified_gmt":"2003-10-01T00:00:00","slug":"alelos-clase-ii-del-sistema-principal-de-histocompatibilidad-en-la-cardiopata%c2%ada-reumatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/alelos-clase-ii-del-sistema-principal-de-histocompatibilidad-en-la-cardiopata%c2%ada-reumatica\/","title":{"rendered":"Alelos clase ii del sistema principal de histocompatibilidad en la cardiopat\u00edareum\u00e1tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmina Flores Dominguez <\/strong><\/h2>\n<p>La cardiopat\u00eda reum\u00e1tica (cr) es una complicaci\u00f3n de la fiebre reum\u00e1tica (fr), la cual es una secuela de una infecci\u00f3n por estreptococo del grupo a nivel far\u00edngeo. No todos los pacientes que padecen una infecci\u00f3n far\u00edngea estreptoc\u00f3cia padecen fr, lo cual se podr\u00eda explicar con la teor\u00eda de la existencia de componentes gen\u00e9ticos que confieran susceptibilidad gen\u00e9tica para padecer la enfermedad. Los alelos codificados en el sistema principal de histocompatibilidad se han relacionado con diversas enfermedades a fin de encontrar dichos componentes, en cuanto a esta enfermedad se cuenta con pocos datos a la fecha.  estudiamos a 98 pacientes mestizo-mexicanos con el diagn\u00f3stico de cr realizado por m\u00e9dicos cardi\u00f3logos  del instituto nacional de cardiolog\u00eda ignacio ch\u00e1vez en m\u00e9xico, d.F y 99 controles sanos no relacionados. Fueron clasificados seg\u00fan el patr\u00f3n de da\u00f1o valvular que presentaron en:  1,- da\u00f1o en v\u00e1lvula mitral.  2,- da\u00f1o multivalvular.  3,- da\u00f1o en v\u00e1lvula a\u00f3rtica.  se obtuvo una muestra de 5-10 ml de sangre de la cual se extrajo adn gen\u00f3mico, el cual fue amplificado por t\u00e9cnica de pcr, determinando los alelos hla mediante t\u00e9cnicas moleculares (kit amplicor). Los resultados se analizaron posteriormente con la prueba del x2, la prueba exacta de fisher y el valor de p fue corregido seg\u00fan yates.  encontramos una frecuencia elevada del alelo hla-dr16 (pc=0.009, rm=3.9,95% ic=1.3-12.2, fe=6.8%) subtipo drb1*1602 en el grupo de pacientes (pc=0.007, rm=5.3, 95% ic=1.4-23.8, fe=6.2%).  la frecuencia del alelo hla-dr11 se encontr\u00f3 disminuido en el grupo de pacientes (pc=0.018, rm=0.33, 95% ic=0.12-0.85) al compararse con los controles. el haplotipo hla-dr16-dqa1*0501-dqb1*0301 se encontr\u00f3o m\u00e1s frecuentemente en el grupo de pacientes que en los controles. Por \u00faltimo, los pacientes que presentaron da\u00f1o multivalvular presentaron una frecuencia elevada del alelo hla-dr16 (pc=0.004, rm=4.8, 95% ic=1.5-<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alelos clase ii del sistema principal de histocompatibilidad en la cardiopat\u00edareum\u00e1tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alelos clase ii del sistema principal de histocompatibilidad en la cardiopat\u00edareum\u00e1tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmina Flores Dominguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Fern\u00e1ndez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Novales huerta m. angeles <\/li>\n<li>auxiliadora Espinar Garc\u00eda (vocal)<\/li>\n<li>alicia Villena garcia-cabrera (vocal)<\/li>\n<li> Mart\u00edn diez m. victoria san (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmina Flores Dominguez La cardiopat\u00eda reum\u00e1tica (cr) es una complicaci\u00f3n de la fiebre reum\u00e1tica (fr), la cual [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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