{"id":21135,"date":"2003-10-01T00:00:00","date_gmt":"2003-10-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-y-evaluacion-farmacologica-de-analogos-de-tacrina-como-agentes-anticolinesterasicos-y-moduladores-de-la-senal-celular-de-calcio-para-el-tratamiento-de-la-enfermedad-de-alzheimer\/"},"modified":"2003-10-01T00:00:00","modified_gmt":"2003-10-01T00:00:00","slug":"sa%c2%adntesis-y-evaluacion-farmacologica-de-analogos-de-tacrina-como-agentes-anticolinesterasicos-y-moduladores-de-la-senal-celular-de-calcio-para-el-tratamiento-de-la-enfermedad-de-alzheimer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-y-evaluacion-farmacologica-de-analogos-de-tacrina-como-agentes-anticolinesterasicos-y-moduladores-de-la-senal-celular-de-calcio-para-el-tratamiento-de-la-enfermedad-de-alzheimer\/","title":{"rendered":"S\u00edntesis y evaluaci\u00f3n farmacol\u00f3gica de an\u00e1logos de tacrina como agentes anticolinester\u00e1sicos y moduladores de la se\u00f1al celular de calcio para el tratamiento de la enfermedad de alzheimer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristobal De Los Rios Salgado <\/strong><\/h2>\n<p>En un proyecto conjunto de s\u00edntesis org\u00e1nica y evaluaci\u00f3n farmacol\u00f3gica, se ha desarrollado la s\u00edntesis de cicloalca[b][1,8]naftiridina-3-carboxilatos de alquilo, 4h-pirano[2,3-b]quinolina-3-carboxilatos de alquilo y cicloalca-4h-pirano[3,2-e]piridina-3-carboxilatos de etilo, que presentan analog\u00eda estructural al inhibidor de la enzima acetilcolinesterasa llamado tacrina (9-amino-1,2,3,4-tetrahidroacridina) y a la familia de ligandos para canales de calcio del subtipo l llamados 1,4-dihidrohidropiridinas.  el objetivo de esta tesis fue el de conseguir nuevos compuestos para el tratamiento de la enfermedad de alzheimer, bajo la hip\u00f3tesis de que, al mimetizar la estructura qu\u00edmica de tacrina y de 1,4-dihidropiridinas, tuvieran a la vez actividad anticolinesterasa y modulaci\u00f3n de la entrada de calcio a trav\u00e9s de estos canales i\u00f3nicos. Esta doble acci\u00f3n farmacol\u00f3gica tendr\u00eda gran beneficio para el freno del progresivo deterioro del paciente, ya que a la actividad anticolinester\u00e1sica, la \u00fanica v\u00eda terap\u00e9utica que hasta el momento ha tenido \u00e9xito; se le suma la actividad moduladora de la se\u00f1al celular de calcio, que tiene gran importancia debido a la implicaci\u00f3n de este cati\u00f3n enprocesos que envuelven a las neuronas, tan diversos como la plasticidad neuronal, neuroprotecci\u00f3n, activaci\u00f3n de los factores tr\u00f3ficos, liberaci\u00f3n de neurotransmisores, expresi\u00f3n de prote\u00ednas, activaci\u00f3n de la apoptosis y\/o necrosis.., Etc.  el proceso sint\u00e9tico parte de aldeh\u00eddos arom\u00e1ticos que por reacci\u00f3n de condensaci\u00f3n de knoevenagel con malononitrilo se transforman en arilidenmalononitrilos, los cuales por reacci\u00f3n de condensaci\u00f3n de michael con acetilacetato de alquilo, a trav\u00e9s de un intermedio 5-oxodinitrilo que sufre una ciclaci\u00f3n espont\u00e1nea 6-exodig, dan estructuras derivadas del 4h-pirano. A partir de los derivados de 4h-pirano. A partir de los derivados de 4h-pirano se obtiene derivados de piridina a trav\u00e9s de una tra<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis y evaluaci\u00f3n farmacol\u00f3gica de an\u00e1logos de tacrina como agentes anticolinester\u00e1sicos y moduladores de la se\u00f1al celular de calcio para el tratamiento de la enfermedad de alzheimer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis y evaluaci\u00f3n farmacol\u00f3gica de an\u00e1logos de tacrina como agentes anticolinester\u00e1sicos y moduladores de la se\u00f1al celular de calcio para el tratamiento de la enfermedad de alzheimer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristobal De Los Rios Salgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Garc\u00eda Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tom\u00e1s Torres cebada <\/li>\n<li>Mar\u00eda  del carmen Carre\u00f1o garcia (vocal)<\/li>\n<li>pelayo Camps Garc\u00eda (vocal)<\/li>\n<li>valent\u00edn Ce\u00f1a callejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristobal De Los Rios Salgado En un proyecto conjunto de s\u00edntesis org\u00e1nica y evaluaci\u00f3n farmacol\u00f3gica, se ha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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