{"id":21166,"date":"2018-03-09T09:10:49","date_gmt":"2018-03-09T09:10:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/optimizacion-de-las-condiciones-biologicas-para-el-trasplante-de-espermatogonias-geneticamente-modificadas\/"},"modified":"2018-03-09T09:10:49","modified_gmt":"2018-03-09T09:10:49","slug":"optimizacion-de-las-condiciones-biologicas-para-el-trasplante-de-espermatogonias-geneticamente-modificadas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/optimizacion-de-las-condiciones-biologicas-para-el-trasplante-de-espermatogonias-geneticamente-modificadas\/","title":{"rendered":"Optimizaci\u00f3n de las condiciones biol\u00f3gicas para el trasplante de espermatogonias gen\u00e9ticamente modificadas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paola Vecino Hern\u00e1ndez <\/strong><\/h2>\n<p>El transplante de espermatogonias es una t\u00e9cnica que podr\u00eda ser una alternativa a los m\u00e9todos convencionales de producci\u00f3n a gran escala de animales transg\u00e9nicos. la ventaja de esta t\u00e9cnica frente a los m\u00e9todos convencionales de creaci\u00f3n de transg\u00e9nicos consiste en la estabilidad del transgen en los animales producidos y en la posibilidad de obtener un gran n\u00famero de animales por cada transplante de espermatogonias gen\u00e9ticamente modificadas. Sin embargo, esta t\u00e9cnica ha presentado un gran n\u00famero de inconvenientes derivados principalmente de la dificultad para conseguir un n\u00famero elevado de espermatogonias para el transplante y de la ineficiencia de los m\u00e9todos de eliminaci\u00f3n de la poblaci\u00f3n end\u00f3gena de la l\u00ednea germinal. Este estudio trata de solucionar ambos problemas, incrementando la poblaci\u00f3n de espermatogonias de partida tanto por m\u00e9todos in vivo como in vitro y eliminando completamente la poblaci\u00f3n end\u00f3gena de la l\u00ednea germinal.  el incremento de espermatogonias in vitro se consigue mediante la transfecci\u00f3n de espermatogonias aisladas de animales prep\u00faberes con un pl\u00e1smido de que contiene el gen que codifica para al ant\u00edgeno t mayor del virus sv40. Los resultados obtenidos permiten mantener las espermatogonias en cultivo durante m\u00e1s tiempo.  por otro lado, el n\u00famero de espermatogonias puede aumentarse in vivo mediante la combinaci\u00f3n de una intervenci\u00f3n quir\u00fargica que inhibe el desarrollo de la espermatog\u00e9nesis (el paso de espermatogonia a espermatocito) y consiste en introducir los test\u00edculos en la cavidad peritoneal y mantenerlos durante un peri\u00f3do de 30 d\u00edas (por sutura del tejido adiposo anexo a la pared peritoneal) y un tratamiento hormonal que acelera la proliferaci\u00f3n de las espermatogonias. este m\u00e9todo permite que puedan aislarse hasta tres veces el n\u00famero de espermatogonias que se obten\u00edan por los m\u00e9todos convencionales.  finalmente, la eliminaci\u00f3n selectiva de las c\u00e9lulas de la l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Optimizaci\u00f3n de las condiciones biol\u00f3gicas para el trasplante de espermatogonias gen\u00e9ticamente modificadas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Optimizaci\u00f3n de las condiciones biol\u00f3gicas para el trasplante de espermatogonias gen\u00e9ticamente modificadas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paola Vecino Hern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Miguel Ar\u00e9chaga Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel jose Gayoso rodriguez <\/li>\n<li>Jos\u00e9 Vaquera orte (vocal)<\/li>\n<li> Alvarez d\u00edaz antonia de los angeles (vocal)<\/li>\n<li>julio Navascues Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paola Vecino Hern\u00e1ndez El transplante de espermatogonias es una t\u00e9cnica que podr\u00eda ser una alternativa a los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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